ID L7W9A9_NONDD Unreviewed; 789 AA.
AC L7W9A9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN Name=pbpC {ECO:0000313|EMBL:AGC76411.1};
GN OrderedLocusNames=DDD_1284 {ECO:0000313|EMBL:AGC76411.1};
OS Nonlabens dokdonensis (strain DSM 17205 / KCTC 12402 / DSW-6) (Donghaeana
OS dokdonensis).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Nonlabens.
OX NCBI_TaxID=592029 {ECO:0000313|EMBL:AGC76411.1, ECO:0000313|Proteomes:UP000011173};
RN [1] {ECO:0000313|EMBL:AGC76411.1, ECO:0000313|Proteomes:UP000011173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17205 / KCTC 12402 / DSW-6
RC {ECO:0000313|Proteomes:UP000011173};
RX PubMed=23292138; DOI=10.1093/gbe/evs134;
RA Kwon S.K., Kim B.K., Song J.Y., Kwak M.J., Lee C.H., Yoon J.H., Oh T.K.,
RA Kim J.F.;
RT "Genomic makeup of the marine flavobacterium Nonlabens (Donghaeana)
RT dokdonensis DSW-6 and identification of a novel class of rhodopsins.";
RL Genome Biol. Evol. 5:187-187(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; CP001397; AGC76411.1; -; Genomic_DNA.
DR RefSeq; WP_015361908.1; NC_020156.1.
DR AlphaFoldDB; L7W9A9; -.
DR STRING; 592029.DDD_1284; -.
DR KEGG; ndo:DDD_1284; -.
DR PATRIC; fig|592029.3.peg.1273; -.
DR eggNOG; COG4953; Bacteria.
DR HOGENOM; CLU_006354_7_2_10; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000011173; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000313|EMBL:AGC76411.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transferase {ECO:0000313|EMBL:AGC76411.1}.
FT DOMAIN 53..219
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 298..418
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 703..783
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 789 AA; 89529 MW; 9E81538DBBCD1BA4 CRC64;
MKKFLFKHKI KLSVLTVLLV WYVVCLPEKL FDVPYSTVIE SKDGRLLDAH IARDEQWRFP
AVDSVPYRYK QSLLQYEDAH FYSHPGFNPV SIGKALADNI SAGKVVRGGS TITQQVIRLA
RKKERKYYEK FIELIWATRL EFRLSKEEIL ELYASHAPYG GNVIGLDMAA WRYFGRKPHE
LSWAESATLA VLPNAPGLVY PGKRESLLKE KRDQVLLKLK EENIITEMDY ELAISENVPT
QDFRVPQLAP HLLQRANKEY GTKKLRTSID YEMQETVNRI VKNHHRILQQ NGVNNLAMLV
LDVESQTVAA YVGNAPTTRE HSKDVDIITA PRSTGSVLKP FLYAAMLEDG ELLPHSLVKD
TPTIIDGFST ENYDKKYTGA IPASQALSRS LNVPAVRLLR EHTVPRFYNK LQDLKLSHLN
RGAGTYGLSL IIGGGESSLW DMSRAYLGMA KTLELYTDNS SQYDPEIMNR LSYLDNSVDL
AFAKAEQPSN NKEISWSLEP SIYGAGSIYH TFEAMKKVNR PEGEEIWHFF NPDREIAWKT
GTSFGNRDAW AIGVTPKYII GVWTGNADGE GRAEMTGIDS AAPVLFDLFN RLPAQQWFAP
PYDDMLEVQT CKQSGYLATP LCEAINQYIP VVGEKYASCP YHKAINLDAT KTYQVNADCE
PASQIITQSW FTLPPVMSYY YSRANPSYQP LPDYRADCVP YTDDVMRFIK PKHNTTITLT
KNVEGELNSA IFEIAHKKSD TEVYWYMDDE FLGATKNFHE LAISGKKGKR LITAVDEDGN
DVRIYVIFE
//
