ID   L7W9F5_NONDD            Unreviewed;       919 AA.
AC   L7W9F5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   Name=kgd {ECO:0000313|EMBL:AGC76842.1};
GN   OrderedLocusNames=DDD_1715 {ECO:0000313|EMBL:AGC76842.1};
OS   Nonlabens dokdonensis (strain DSM 17205 / KCTC 12402 / DSW-6) (Donghaeana
OS   dokdonensis).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Nonlabens.
OX   NCBI_TaxID=592029 {ECO:0000313|EMBL:AGC76842.1, ECO:0000313|Proteomes:UP000011173};
RN   [1] {ECO:0000313|EMBL:AGC76842.1, ECO:0000313|Proteomes:UP000011173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17205 / KCTC 12402 / DSW-6
RC   {ECO:0000313|Proteomes:UP000011173};
RX   PubMed=23292138; DOI=10.1093/gbe/evs134;
RA   Kwon S.K., Kim B.K., Song J.Y., Kwak M.J., Lee C.H., Yoon J.H., Oh T.K.,
RA   Kim J.F.;
RT   "Genomic makeup of the marine flavobacterium Nonlabens (Donghaeana)
RT   dokdonensis DSW-6 and identification of a novel class of rhodopsins.";
RL   Genome Biol. Evol. 5:187-187(2013).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP001397; AGC76842.1; -; Genomic_DNA.
DR   RefSeq; WP_015362339.1; NC_020156.1.
DR   AlphaFoldDB; L7W9F5; -.
DR   STRING; 592029.DDD_1715; -.
DR   KEGG; ndo:DDD_1715; -.
DR   PATRIC; fig|592029.3.peg.1698; -.
DR   eggNOG; COG0567; Bacteria.
DR   HOGENOM; CLU_004709_1_0_10; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000011173; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AGC76842.1};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          582..775
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   919 AA;  105256 MW;  E8269BDE84445363 CRC64;
     MDKFSFLNAA HTAYFAQLYD EYLINPDKIE PSWRAFFQGF DFGMESATDG DVVVEYIERG
     ESKSTQVPDQ MMKEFSVVKL IDAYRSRGHL FTKTNPVRER RNYEPKLGLE NFGLTNADLD
     TLFDSGELIG LGKASLKSII DHLEQVYCDS IGVEYMYIRK PHEIKWIQSW LHRNNNHPSF
     SKEQKTQILK KLNEAVSFES FLHTKYVGQK RFSLEGNESL IPALDALIEN AADKGVDQFI
     LGMAHRGRLN VLTNIFGKPV KDIFSEFDGK DYEQDIFDGD VKYHLGYTSK RKTDNGNDIN
     LNIVPNPSHL ETVGAVVEGI ARAKQDMHNP ENFSKVLPIV LHGDAAIAGQ GIVYEVVQMS
     QLDAYKTAGT IHLVVNNQVG FTTNYLDARS STYCTDVAKV TLSPVLHVNA DDAEAVVHAM
     NFALDYRMEF GRDVFIDLLG YRKYGHNEGD EPRFTQPQLY KAIGKHKNPR DIYADKLLQE
     GLIDNSKVKE LEAQYKERLE EELATSRQME NTIITPFMQD EWNGFEQATE VEMMQQVETG
     VDRDTLEKIT ATISQLPEGE SFIRKIKKII ESRQKMWDED KLDWAMGEHL AYGSLMMEGY
     NVRMSGQDVE RGTFSHRHAV VKSENHENEF ILHNHIDGVK GKMDIYNSHL SEYGVVGFEY
     GYALARPNTL TIWEAQFGDF SNGAQIMMDQ YISAGEDKWK NQNGLVKLLP HGYEGQGAEH
     SSARIERYLQ LCARDNMFMA NCTTPANMFH LLRRQMLVNY RKPLVVFTPK SLLRYPKAVS
     TISEFENGHF QEVIDVDGDA FAKAKTLVFT SGKFYYDLLE YREENKRTDV ALVRLEQLFP
     LPVEQMQEII KKYGSKDIVW AQEEPRNMGA YSHLMLHMPE TRSWRVCSRN MYAAPASGSS
     TRSKRRQARI IEDVFNTNK
//