ID   L8DMI6_9NOCA            Unreviewed;       795 AA.
AC   L8DMI6;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Topoisomerase IA {ECO:0000313|EMBL:CCQ18122.1};
GN   ORFNames=RHODMAR_4737 {ECO:0000313|EMBL:CCQ18122.1};
OS   Rhodococcus sp. AW25M09.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=1268303 {ECO:0000313|EMBL:CCQ18122.1, ECO:0000313|Proteomes:UP000011207};
RN   [1] {ECO:0000313|EMBL:CCQ18122.1, ECO:0000313|Proteomes:UP000011207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AW25M09 {ECO:0000313|EMBL:CCQ18122.1,
RC   ECO:0000313|Proteomes:UP000011207};
RA   Hjerde E., Pierechod M.M., Williamson A.K., Bjerga G., Willassen N.P.,
RA   Smalaas A.O., Altermark B.;
RT   "Draft genome sequence of Rhodococcus sp. AW25M09. An Actinomycete isolated
RT   from Atlantic Hagfish caught in Hadselfjorden, North- Norway.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCQ18122.1}.
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DR   EMBL; CAPS01000135; CCQ18122.1; -; Genomic_DNA.
DR   RefSeq; WP_008720283.1; NZ_CAPS01000135.1.
DR   AlphaFoldDB; L8DMI6; -.
DR   STRING; 1268303.RHODMAR_4737; -.
DR   eggNOG; COG0550; Bacteria.
DR   OrthoDB; 9803554at2; -.
DR   Proteomes; UP000011207; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00186; TOP1Ac; 1.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CCQ18122.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          3..153
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   REGION          256..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   795 AA;  86726 MW;  442C34A1ED97ED73 CRC64;
     MGKVGILTEK PSAARNFATA LGGMSGTFAG TEYVIVHARG HLLELKDPSA MVPAPLTDKY
     KSWELEHLPW NADDFRWERE IRRRVSGGKL VTDPDAKSLL LELKATLSGC ESICNAADLD
     PTGEGSLLGW EIVEYLGLEN KKLERMEFLD ETPASLRKAF TARRPVTAIA AEGDYRKADF
     RSKWDMLSMQ FTRLATKTAG ATTVLRNGRL KSAMVVIVGD GLDAHHGYVK KAFYENRFRD
     ENGVTYTDPE VDRFENENDV PGGLQSSPVV HDGTTRKKTG PPKLMDLAGL SSLLAKKGFG
     AKNVLDTYQK MYEAQVVSYP RTEDKFISIE QFNELLPSVD AIAGVVGVDP AALSHRGPRT
     SHVKSGGAHG ANRPGPNVPP SLAAVEKAYG ELGKEIYELL AKNYLTMLAP DYEYDQHRGH
     VEQYPSFVGS LNVPAVLGWK GVFVVEEEHG ERDEQPTGAT ALGTVADPFV HEGFPPRPPH
     PTMGWLMKQL EKRSVGTGAT RTSTYAEVTN NSAGKALMVD KRGKITLSAI GELNHRILPG
     THIGDLTITE QVFEQMAQIQ AGTGEAADYL SLVADLVRHD LKTMTANASM LSGELTARMG
     KAGVTRETVE MIDLPPELHF THAGTVVTRA KRVFGGHRFT DTEVAALLAG QVIEIAATSA
     KSGKTFTCTG KLEPGVRDKD GKQYPHVSFN PQFEERAPRT DLVSGVWKGK PVTFKGRGWG
     ANDHWSGKDF TEQELASLLA GDTIEFDATS KTGKTYRAKG ALAAGTYQGS KTFGFKLKFE
     DRKSTAGTKK RTVRR
//