ID L8E811_CAEEL Unreviewed; 427 AA.
AC L8E811;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=TIL domain-containing protein {ECO:0000313|EMBL:CCQ25690.1};
GN ORFNames=CELE_Y69H2.3 {ECO:0000313|EMBL:CCQ25690.1}, Y69H2.3
GN {ECO:0000313|EMBL:CCQ25690.1, ECO:0000313|WormBase:Y69H2.3g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCQ25690.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCQ25690.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCQ25690.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; BX284605; CCQ25690.1; -; Genomic_DNA.
DR RefSeq; NP_001263926.1; NM_001276997.1.
DR AlphaFoldDB; L8E811; -.
DR SMR; L8E811; -.
DR EPD; L8E811; -.
DR PeptideAtlas; L8E811; -.
DR EnsemblMetazoa; Y69H2.3g.1; Y69H2.3g.1; WBGene00013481.
DR GeneID; 180221; -.
DR AGR; WB:WBGene00013481; -.
DR WormBase; Y69H2.3g; CE48143; WBGene00013481; -.
DR HOGENOM; CLU_518010_0_0_1; -.
DR OrthoDB; 2879047at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013481; Expressed in adult organism and 4 other cell types or tissues.
DR ExpressionAtlas; L8E811; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR PANTHER; PTHR23259; RIDDLE; 1.
DR PANTHER; PTHR23259:SF77; SERINE PROTEASE INHIBITOR 1 PROTEIN-RELATED; 1.
DR Pfam; PF01826; TIL; 3.
DR SUPFAM; SSF57567; Serine protease inhibitors; 3.
PE 1: Evidence at protein level;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteomics identification {ECO:0007829|EPD:L8E811,
KW ECO:0007829|PeptideAtlas:L8E811};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..427
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003987811"
FT DOMAIN 26..80
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
FT DOMAIN 99..155
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
FT DOMAIN 365..419
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
SQ SEQUENCE 427 AA; 46185 MW; CC6BAD55D12535F7 CRC64;
MQYIVLLSVL LIGANAQLSA TRDQECKENE SFQTCGTACE PTCGLPTPTF CTLQCVMGCQ
CNSGFFRRTS DNRCVEQKDC NVAANETIPI PPPATNLTCP VNEVSNECHN PCTEKKCPQK
NAPQVNCLMA CQVGCSCMDG FVRNNQGVCV KEAECPAIGS TDENPCNLVD CRTGHQCSMS
TGKPTCVPET PPTGITCANV RCGFKGGCGM VEPVGCVGCK RQPQCLEEDY CRAQNCPYNE
ECVLVQVTCI RAPCNPIPTC RPKDLRLIKP LIQPRERRQA GPSCMTARCG TPAGCAMVRP
SGCIGSTVEK GCELMPMCIH VNACASTSCL VGSQCVLHQV QCFTQPCDPI AQCEAPIKKP
INRRCRSNEK FEPCKTVCSD TKCNEEPRFC PQVCTGGGCV CQEGFFRDNS GKCVTQNDCD
AQKPKLY
//