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Database: UniProt
Entry: L8EV77_STRR1
LinkDB: L8EV77_STRR1
Original site: L8EV77_STRR1 
ID   L8EV77_STRR1            Unreviewed;       529 AA.
AC   L8EV77;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Small RNA 2'-O-methyltransferase {ECO:0000256|ARBA:ARBA00021330};
DE            EC=2.1.1.386 {ECO:0000256|ARBA:ARBA00035025};
GN   ORFNames=SRIM_031515 {ECO:0000313|EMBL:QST84100.1};
OS   Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM
OS   4667 / NRRL 2234).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1265868 {ECO:0000313|EMBL:QST84100.1, ECO:0000313|Proteomes:UP000011074};
RN   [1] {ECO:0000313|EMBL:QST84100.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 10970 {ECO:0000313|EMBL:QST84100.1};
RA   Pethick F.E., MacFadyen A.C., Tang Z., Sangal V., Tze-Tze L., Chu J.,
RA   Guo M., Kirby R., Hoskisson P.A., Herron P.R., Hunter I.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QST84100.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 10970 {ECO:0000313|EMBL:QST84100.1};
RA   Algora L., Schniete J.K., MacFadyen A., Hoskisson P.A., Hunter I.S.,
RA   Herron P.R.;
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:QST84100.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 10970 {ECO:0000313|EMBL:QST84100.1};
RA   Algora-Gallardo L., Schniete J.K., Mark D.R., Hunter I.S., Herron P.R.;
RT   "Bilateral symmetry of linear streptomycete chromosomes.";
RL   bioRxiv 0:0-0(2021).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) +
CC         S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide;
CC         Xref=Rhea:RHEA:37887, Rhea:RHEA-COMP:10415, Rhea:RHEA-COMP:10416,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74896, ChEBI:CHEBI:74898; EC=2.1.1.386;
CC         Evidence={ECO:0000256|ARBA:ARBA00034992};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. HEN1 family.
CC       {ECO:0000256|ARBA:ARBA00009026}.
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DR   EMBL; CP048261; QST84100.1; -; Genomic_DNA.
DR   RefSeq; WP_003980841.1; NZ_CP048261.1.
DR   AlphaFoldDB; L8EV77; -.
DR   GeneID; 66858603; -.
DR   OMA; AKHYWVA; -.
DR   Proteomes; UP000011074; Chromosome.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.30.1610.20; Hen1, N-terminal domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR024026; 3'-RNA_MeTfrase_Hen1_bac.
DR   InterPro; IPR026610; Hen1.
DR   InterPro; IPR024740; Hen1_N.
DR   InterPro; IPR038546; Hen1_N_sf.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR04074; bacter_Hen1; 1.
DR   PANTHER; PTHR21404; HEN1; 1.
DR   PANTHER; PTHR21404:SF3; SMALL RNA 2'-O-METHYLTRANSFERASE; 1.
DR   Pfam; PF12623; Hen1_L; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:QST84100.1};
KW   RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:QST84100.1}.
FT   DOMAIN          1..248
FT                   /note="Hen1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12623"
FT   DOMAIN          325..415
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
SQ   SEQUENCE   529 AA;  57973 MW;  A78371473901C5CA CRC64;
     MFLTITTTGS DGRPATDLGF LLHKHPGKAQ AFSTAYGTAH VFYPEADDGR CTAALLLEVD
     PVALVRRGRG KGRGGAPDSA LAQYVNDRPY AASSLLAVAL STVFASALKG QCKARPELPA
     QPRPLRLDLP AVPARGGAEL VRRLFEPLGW TVRAEPVPLD ATFPEWGDSR YVRLGLEGEH
     TVAEALRHLY VLLPVLDDAK HYWVAPDEVD KLLRAGEGWL ADHPEQKLIT GRYLARRWSL
     TRDALERLEL ARLAEADDTA AEEIDNAVEE SLETEAGEPA GTEAAEPAEA TEQAGGTGER
     PVPLAVQRRA AILGVLREVK AARVLDLGCG QGQLLGDLLK EPRFTDIVGL DVSMRALQET
     RRRLRLDRMP ERQSERLRLV QGSLAYTDAR LKGYDAAVLS EVVEHVDPPR LSALEYAVFG
     AARPRSVVVT TPNVEYNVRW ESLPAGHVRH RDHRFEWTRE EFRAWSGEVA ERHGYEVEFR
     PVGPDDPEVG PPTQLAHFRL AADRVSVPAP ARPASVPTTA LTPAKEAQA
//
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