ID L8FMM9_PSED2 Unreviewed; 529 AA.
AC L8FMM9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=GID complex subunit containing RING finger motif {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_00950 {ECO:0000313|EMBL:ELR02157.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR02157.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the proteasome-dependent degradation of fructose-
CC 1,6-bisphosphatase. {ECO:0000256|ARBA:ARBA00002343}.
CC -!- SIMILARITY: Belongs to the FYV10 family.
CC {ECO:0000256|ARBA:ARBA00010615}.
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DR EMBL; GL573179; ELR02157.1; -; Genomic_DNA.
DR RefSeq; XP_012739345.1; XM_012883891.1.
DR AlphaFoldDB; L8FMM9; -.
DR STRING; 658429.L8FMM9; -.
DR VEuPathDB; FungiDB:GMDG_00950; -.
DR HOGENOM; CLU_027445_2_0_1; -.
DR InParanoid; L8FMM9; -.
DR OrthoDB; 1429623at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:UniProt.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR InterPro; IPR013144; CRA_dom.
DR InterPro; IPR024964; CTLH/CRA.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR045098; Fyv10_fam.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR044063; ZF_RING_GID.
DR PANTHER; PTHR12170:SF2; E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA; 1.
DR PANTHER; PTHR12170; MACROPHAGE ERYTHROBLAST ATTACHER-RELATED; 1.
DR Pfam; PF10607; CTLH; 1.
DR SMART; SM00757; CRA; 1.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00667; LisH; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS51867; ZF_RING_GID; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01215}.
FT DOMAIN 285..342
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT DOMAIN 453..514
FT /note="RING-Gid-type"
FT /evidence="ECO:0000259|PROSITE:PS51867"
FT ZN_FING 453..514
FT /note="RING-Gid-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01215"
SQ SEQUENCE 529 AA; 59198 MW; C2D21B33C32C5121 CRC64;
MTNRANYAPK RFKVQGRKYG VRETSLSLFR CVESAGEQVA STSCPRRITA GVRSTSTVRR
VRRVGEAEWQ SGRVAEYGEY GEYSECGKYG KYGYRIRGGH QGYRWASKRL HCCLTSTTTS
TAMADHTASK LNPDTHLILD QQLLRLPYEL LRKNFKVAQL SVERDSTAVK QSLKDTANAC
LSNSSTPDEV LKNLDSMIAR MRGLKRKLAA CAEEEKRLQS HSQARIRHLG ALYSMQSLDD
VKYEVWSRTR LDRLLVDYML RNGYVQSAAA LTQEKQIEEL VDTGTFIQMG KIRDSLRNGR
VNEVLAWCTE NKKELRRMGS KLEFMVRFQQ YIELARTRDQ GKLQDAIVHA KKYLLPSKDL
YPSEVKQAAG LLAFPPEAGL AIYSNLYAAH RWEDLAKLFM ETHNSLLSIP AVPLLHIALS
AGLSALKTPS CHSSHLSSSA SPSSSSSITS SVCPICSTEL NALARNVPYA NHTSSRVDPD
AVLLPNSRVY GRAKLEDYSR KAGLDKGFVK DLTTGMVFEI ANAKKVYIS
//
