ID L8FSG0_PSED2 Unreviewed; 1219 AA.
AC L8FSG0;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Ras guanine nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_05589 {ECO:0000313|EMBL:ELR02626.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR02626.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL573289; ELR02626.1; -; Genomic_DNA.
DR RefSeq; XP_012744020.1; XM_012888566.1.
DR AlphaFoldDB; L8FSG0; -.
DR STRING; 658429.L8FSG0; -.
DR VEuPathDB; FungiDB:GMDG_05589; -.
DR HOGENOM; CLU_002116_1_0_1; -.
DR InParanoid; L8FSG0; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 79..145
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 745..865
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 925..1172
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 134758 MW; ABE43BB6E79837E8 CRC64;
MATMREHSER SAHVTPLHIH RGHYSQSSVD MTSNSGTVRQ NDNASEYSGY SCTQITPPAS
PSAYDDDVTM TEMDYPQPVF HNYLRAVYPF NRAESPLEPA VTLHLNKGDV VLVYSIHTNG
WADGTLLLDG DRGWVPTNFC ENYEPEEMRS LLRALISFSD LLKSGITADD EIFSNQEFIK
GIIAGVRLLL ERSNCLTRDS PFVLSNEIVR RSRRSLLSDV SSLVKTSKHL QAYREHMFTM
TEPGNISQGI IDEMLLKAFK IVTRGVRFHD ACLADLESQY TLNRITSLTR EPYDPSTPPA
DVTTFQNAMS RASAGSRRES LRVSRGGASR EEAAEEQTKR QSFKRTSSVF SPTTKNPRRQ
SSMQLSRQSL SHRLSTAGQH LDARRQNYLS ELLGKAHETF ISCLGSLVGR LHLAHGSNDL
LTSIRQAIAA GKALGTIIEL LCARDVRNEA SLQDVRDTMY QCINQLVIAA RECVGPSSSD
GEDNVILQKD HDSIESAATG CVVAVGECVE RAKSLIEIVG DFELEPSALG IDVSAFAADV
ATDNNPRIVE ESTLEEPASL PPPPPTGFDF EKTLPPSVTD MEKPLPSFVI IDQEKPLPHV
PESEAETSDD AQMGLIGTAK TTLAPSPTFL PALKLGGPMG GLQLQTSIPS NDLLSSRSDS
VATCTGSPST YMSSLRGSEA SLVSQTSTRA TTPELSCHRQ SHQSHQMSKS VNSIPESQAT
SADEREDDES RVLEKTFAHE LIFNKERQVT GGSLPALVER LTSHDSTPDA IFVSTFYLTF
RLFATPITFS EALIERFNYV NESLHIAAPV RLRVYNVFKG WLETHWQHTA DKVALPLIRS
FAGTTLLSVL PQAGRRLSEL AEKVAATEEP ITPRLLSSIG KTSTSIAQYI SPDTPLPSPI
LSKSQINSLK TWKMGGSSPS ILDFSPVEMA RQLTIKEMNV FCTIMPEELL ASEWMKKSGS
NAVNVKAMST LSTDLSNLVA DTVLQSESDA KKRAVIIKHW IKIANECLIL NNYDSLMAII
CSINSSMITR LKKTWDMISP KRKEMLKVLQ DIVEPTKNHA VLRQRLQGHV PPCLPFVGTY
LTDLTFVDMG NPATKQLTGS AGEKGMAVIN FDKHTRTAKI IGDLQRFQIP YRLAEVPELQ
EWIQAQVIRV RASNDSNNVQ QYYRKSLLLE PRMTQKTSPV DFQGAFSHPT PILTKEKFDL
FSWAHTRDKL ALTPTPTNS
//