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Database: UniProt
Entry: L8FSG0_PSED2
LinkDB: L8FSG0_PSED2
Original site: L8FSG0_PSED2 
ID   L8FSG0_PSED2            Unreviewed;      1219 AA.
AC   L8FSG0;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=Ras guanine nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GMDG_05589 {ECO:0000313|EMBL:ELR02626.1};
OS   Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS   white-nose syndrome fungus) (Geomyces destructans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR02626.1, ECO:0000313|Proteomes:UP000011064};
RN   [1] {ECO:0000313|Proteomes:UP000011064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA   Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Geomyces destructans 20631-21.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL573289; ELR02626.1; -; Genomic_DNA.
DR   RefSeq; XP_012744020.1; XM_012888566.1.
DR   AlphaFoldDB; L8FSG0; -.
DR   STRING; 658429.L8FSG0; -.
DR   VEuPathDB; FungiDB:GMDG_05589; -.
DR   HOGENOM; CLU_002116_1_0_1; -.
DR   InParanoid; L8FSG0; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000011064; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   CDD; cd00174; SH3; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          79..145
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          745..865
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          925..1172
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..719
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1219 AA;  134758 MW;  ABE43BB6E79837E8 CRC64;
     MATMREHSER SAHVTPLHIH RGHYSQSSVD MTSNSGTVRQ NDNASEYSGY SCTQITPPAS
     PSAYDDDVTM TEMDYPQPVF HNYLRAVYPF NRAESPLEPA VTLHLNKGDV VLVYSIHTNG
     WADGTLLLDG DRGWVPTNFC ENYEPEEMRS LLRALISFSD LLKSGITADD EIFSNQEFIK
     GIIAGVRLLL ERSNCLTRDS PFVLSNEIVR RSRRSLLSDV SSLVKTSKHL QAYREHMFTM
     TEPGNISQGI IDEMLLKAFK IVTRGVRFHD ACLADLESQY TLNRITSLTR EPYDPSTPPA
     DVTTFQNAMS RASAGSRRES LRVSRGGASR EEAAEEQTKR QSFKRTSSVF SPTTKNPRRQ
     SSMQLSRQSL SHRLSTAGQH LDARRQNYLS ELLGKAHETF ISCLGSLVGR LHLAHGSNDL
     LTSIRQAIAA GKALGTIIEL LCARDVRNEA SLQDVRDTMY QCINQLVIAA RECVGPSSSD
     GEDNVILQKD HDSIESAATG CVVAVGECVE RAKSLIEIVG DFELEPSALG IDVSAFAADV
     ATDNNPRIVE ESTLEEPASL PPPPPTGFDF EKTLPPSVTD MEKPLPSFVI IDQEKPLPHV
     PESEAETSDD AQMGLIGTAK TTLAPSPTFL PALKLGGPMG GLQLQTSIPS NDLLSSRSDS
     VATCTGSPST YMSSLRGSEA SLVSQTSTRA TTPELSCHRQ SHQSHQMSKS VNSIPESQAT
     SADEREDDES RVLEKTFAHE LIFNKERQVT GGSLPALVER LTSHDSTPDA IFVSTFYLTF
     RLFATPITFS EALIERFNYV NESLHIAAPV RLRVYNVFKG WLETHWQHTA DKVALPLIRS
     FAGTTLLSVL PQAGRRLSEL AEKVAATEEP ITPRLLSSIG KTSTSIAQYI SPDTPLPSPI
     LSKSQINSLK TWKMGGSSPS ILDFSPVEMA RQLTIKEMNV FCTIMPEELL ASEWMKKSGS
     NAVNVKAMST LSTDLSNLVA DTVLQSESDA KKRAVIIKHW IKIANECLIL NNYDSLMAII
     CSINSSMITR LKKTWDMISP KRKEMLKVLQ DIVEPTKNHA VLRQRLQGHV PPCLPFVGTY
     LTDLTFVDMG NPATKQLTGS AGEKGMAVIN FDKHTRTAKI IGDLQRFQIP YRLAEVPELQ
     EWIQAQVIRV RASNDSNNVQ QYYRKSLLLE PRMTQKTSPV DFQGAFSHPT PILTKEKFDL
     FSWAHTRDKL ALTPTPTNS
//
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