ID L8FWB5_PSED2 Unreviewed; 820 AA.
AC L8FWB5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Disintegrin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_07199 {ECO:0000313|EMBL:ELR05157.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR05157.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR EMBL; GL573374; ELR05157.1; -; Genomic_DNA.
DR RefSeq; XP_012745649.1; XM_012890195.1.
DR AlphaFoldDB; L8FWB5; -.
DR STRING; 658429.L8FWB5; -.
DR VEuPathDB; FungiDB:GMDG_07199; -.
DR HOGENOM; CLU_012383_1_0_1; -.
DR InParanoid; L8FWB5; -.
DR OrthoDB; 2961161at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04271; ZnMc_ADAM_fungal; 1.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR034028; ZnMc_ADAM_fungal.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF159; MIND-MELD, ISOFORM J; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF13688; Reprolysin_5; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..820
FT /note="Disintegrin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003989273"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..497
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 522..614
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT REGION 741..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 434
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 438
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 444
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 820 AA; 87528 MW; A4CF5FE70692B6F5 CRC64;
MRLLRCVAAA LVSAGFSHIA QAHSVKRAPL SYLSIVDEPV IHTPSHRVHA YSSFDLSFHL
HARQQYIKLT LDPNDDVIVE GATVNYIGAD GQVREVELIE RSDHRVFKGH AWVRTHEDTQ
WTHAGWARVV IHRDGVDPLF EGAFRIDGNH HHIHPRNSYV ATKHELDPYV EDDREDIMVV
WRDSDITPDE SNRGELKRDV NTGSCLSDDL IFNLMPEHPV YNQVYSQSPV LRRGESYWGS
ISSGSIFGRD IDPTGNLPGN GAAVNLMNSI GNPAGCPTSR KVALVGIATD CTYTKFFNSS
SSVRANIITQ MNSASVLYEE SFNISLGIQN LTITDGTCPG VSQVNTPWNR DCNSGLQIQD
RLNLFSAWRG ASQDTNAYWT LLTTCGTGSA VGLSWLGQAC VNTAQPSTQG GSNDTVSGAN
VVVKTDTEWL VIAHEVGHTF GAVHDCDSTT CADGKTVAAQ QCCPLSKNSC SAGGKYVMNP
STGVGITNFS PCSIGNICSA IGGQSVKTNC LTSNRNVPTI TGSQCGNGIV EMGEDCDCGG
ATGCGDNPCC NPTTCKFKTQ NNAVCDPSNE DCCLSTCQFA TQGTICRAST SDCDPQETCS
GTAASCPADT HADEGSSCGA SGDGLTCASG QCTSRDKQCK TLMGPQYYQC SDDGCQLFCA
TDASQYYCEG LTQNFLDGTK CGGGGKCSNG ACKGSTVGGR IKEWVDQHKP LVIGLSASVG
GLLLLAIISC IFSSCKRRSR QRKYAPNAPP PPRGRAGWAP QGQGRGYAVV PTPRMQQRGM
GGMGMGAPPP QYEYGAGGQQ YDGQWNVPQR AYGGAPVRYA
//
