ID L8FYW5_PSED2 Unreviewed; 1529 AA.
AC L8FYW5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=GMDG_07855 {ECO:0000313|EMBL:ELR06200.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR06200.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; GL573434; ELR06200.1; -; Genomic_DNA.
DR RefSeq; XP_012746309.1; XM_012890855.1.
DR STRING; 658429.L8FYW5; -.
DR VEuPathDB; FungiDB:GMDG_07855; -.
DR HOGENOM; CLU_003836_1_0_1; -.
DR InParanoid; L8FYW5; -.
DR OrthoDB; 317994at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF54; DNA METHYLTRANSFERASE DIM-2; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 430..558
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 579..702
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 815
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1529 AA; 170138 MW; A35AD9A353AA01B6 CRC64;
MPPWITEEDD EDVEHGYITP QLSFTPPSPR GSDDDSEQDD PSPSPEFPVE ISDFSPEDDS
LVELIDTALD LQSKPQKKIL HHLRQSEFIY PLSGYQGNTP PLSLSKEWQV VKDFQELVKQ
ENPSGLNASY GDDKFLEIEL SQFFIYLPGT NGHHAYEMTG LQDLITRPGN PLYCFDGILS
VGGQKRYVQG VPFKLVSVAG YGIEFDEVEH VWIKSCANSR SNVYYRLKEP HPHYKRYHDG
YLWLANLSKH FVDYALEVAE AGRKVSIHNF RRDFADRMGK EHRESASFQE WLKKYNGRDF
RSALTSNIDF IAKDAIGTYM LDDLDIWAEV KYKTAIPFHE PKETMTAVTP YVYDCFEHMK
FGSHLKKVHP SIQSQIRRES QGNALHLTLD AEFTEENPDL QTQTSITPAA KSRKVKGSLQ
QFCSRPFDVK SISVGDVLGV KTDGVGSSWK DEETHWKEPD ECWYVYVQGV HTTQSGNRSF
HVLWLYRPAD TACALMKYPH GDELFLSDNC SCSTSRISED EVLCKVSVAW DGNPGQTEAD
FFIRQTYESD NSFVTFKEEH KLCDHLVVNV TTPIQKLAEQ YKIGDTVLVN PKGCFKSNFG
LEPCEIIGFV QGIISFVRVR RLLRRREIGD DTPARPNELV YSDDMASIDA DEVYRRCFVR
FYSQSQIINK EVPAPYCRDG TGDMFYIASR LVRLDDKNHL KEIDSTSRPQ SLIQGFDPTQ
PPPFRRLRGL DMFCGGGNFG RGLEEAGAIK FTHAVDMAPN AIATYYANTE DPTTTQFFCG
SVDDMLIKAL SGNVEGALEI PLPGDIDFIA AGSPCVGYSI LNPNKDSAQG LKNQSLIADV
ASMIDFYRPK YALLENVLTM AQKGKGRNHD SLSQLICCIV GMGYQLQVYV LDAWSFGSPQ
GRSRLFVSVA APGFKLPPRP DCSHSHPNGT SDRGLGTMAN GKAFGERLFV ETPFKFVSAA
EATEHLPDIG DGHPGHCSQY PDHRPSRSPR DTLRQHMNII PFSPPGMNFI KTWKNRHITG
MTKHDYENFN TVTKKGKQRH NAMEFSRAYG RIVPTSLFST IVTNCSPENA RSGRVLHWSQ
PRLLTIEEAK IAQGFVQGDA LTGTRGEQYK IAGNSVARTV ALAQGLSYRE VWLKNGPEED
DTGEVPVAEQ IQKQLFADMI TSDDRGEFTA IPDSNSSSGD VSEDRYCRAL DKLKLSSPAK
TDDDISSLSS STSGAPQTTR KRHKTQNDIP ISPTNPPPSL PKSRFPPTVA ARLGVDVAAV
RAEHAMEQAA KRKAERVASA SRFSIRNAIE DAFGAEGDSS QEGKVSKAKR TPLPVRAPAR
ATVVGESSPL SARRRKKIAW LKDRMGSTVE GRKRPDEAFN LWPTPQVTKR GNIRGQIQST
AGSTLQPAKA QGGASDEQMS KKRKTTASDT ASPSMPQTGI QTAKTPASTS EEQSPKRRRT
AASSTSNTAT AGASHSQTHT ARRRPPKSKT QFVIDLTGDS DVERRGDRRV YVPVDNSMFG
AYEMTYNSSM VGMRDPAVVV DGVNGPFAY
//
