ID L8G3P4_PSED2 Unreviewed; 1343 AA.
AC L8G3P4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GMDG_08354 {ECO:0000313|EMBL:ELR07283.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR07283.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL573516; ELR07283.1; -; Genomic_DNA.
DR RefSeq; XP_012746815.1; XM_012891361.1.
DR STRING; 658429.L8G3P4; -.
DR VEuPathDB; FungiDB:GMDG_08354; -.
DR HOGENOM; CLU_001883_4_0_1; -.
DR InParanoid; L8G3P4; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF72; GH08340P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..627
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 638..725
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 32..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1047
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1343 AA; 145459 MW; FFDE5D20C7D9C1AB CRC64;
MAPGNDHPPT NRPTFQTRTA VDVAGELNSR FSVFVDDSTP SQETQFGGDK PSGSNEALSS
GTSKGGSILS SPFNFTKRVL NIHTGSSSTE TTPLLRKRTT TNGQKSQTSP TRAGPHADQR
NPDGDDKRTK PGLGPRPVGG SDKLGTFSGV FVPTCLNVLS ILMFLRFGFI LGQAGVLGIM
GMLVAAYSID LITIFSLSAI ASNGTVRGGG AYYLISRSLG PEFGGAIGLV FYMGQVFNTG
LNAVALVDAI QNNIGAATGD WARILPESQG YNYLWATVVL LVCTGTCLAG SGVFARASNG
LLIILLISTM SIPFSALVMA PFESRQLGIQ FTGVSLDTFK GNLFPRFTKG AAGSQSKGRE
SFQGLFGILF PATSGIFAGA SMSGDLKHPS KAIPKGTLWA LALTFVLYTL VILSLACTVT
RASFVADINI IQDTNVSAAL VLAGEFATTF FSTLMGVIGC AKLMQALARD ELYPGLSIFG
QGTKKADEPV YAICFTYLAA QIVMLFDINQ IASLITMAYL MTFLVMNLAT FLLKIGSAPN
FRPSFHFFSW QTAFLGAVFS GTAMIFVDGV YASVCVAILI VLFLLVHYTS RPRSWGDVSQ
SLIYHQVRKY LLRLKPEHVK FWRPQILLFV NDPRRQYKLI QFCNSMKKGS LYILGHVVVS
DDFGRTVPEA RRQQVAWSKY IEFSNVKAFV NIAISPTLEW GVRNLSLSAG LGGMRPNIAV
IGFYNMDDLN KSKSTTLSSP TDAAGTQTPS DGYDQEAPKD GPSDDTSGLK LAAQLPTDSC
QTESTTSIMS YVTVLEDLLL RLQINVAVAR GFNGLEIPNP KGHNKKNILI SGLSRYTLIL
QLGCILNTVP SWKKSYKLRV AVFVEYETDV EEERIRVKSL LENLRIQAEV KVFWLASGSL
PTYEIIVNGN SSGPEAEAEV EECLKDQEWW EEMQKIRGKR GQPLASGLGL NVENLLGSSA
WPDASFQQGP RHEKVERFLG LRNLLHKSKR RRTMSGFSKL GVNLGMRAQR LPAQLTHRAS
SERDYSDSES SSDDSDEDND DDQSIASEAD ADDRKLDSDG DLRSSTKLVR RKSHGDAMQG
PRSARNLVAP KELTLKNKSK SNTASNTTTP ARSLKDFDTS GGAPSLKESQ DANTAPTTSS
NMEPPPRKLE ERFSALRQSP SKSQLSPTKP SHASGARERP ILSRHASSQK FSSKPVPVSQ
VASQDGAGPS IMFIDTPSPS TKHSRLQSAY CSSQDNNDNG GTSSNNPSSS PPKSLGSTYS
TQSLPLSFND LPCRAQHLIL NELMRQNSKD TAVMFTTLPS PSPGTHQDEE ACIAYISDLQ
VLGRGCPPCL MVHSNSMTVT MSL
//
