ID L8G6K2_PSED2 Unreviewed; 2500 AA.
AC L8G6K2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Helicase C-terminal domain-containing protein {ECO:0000259|PROSITE:PS51194};
GN ORFNames=GMDG_03106 {ECO:0000313|EMBL:ELR08308.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR08308.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GL573215; ELR08308.1; -; Genomic_DNA.
DR RefSeq; XP_012741518.1; XM_012886064.1.
DR STRING; 658429.L8G6K2; -.
DR VEuPathDB; FungiDB:GMDG_03106; -.
DR HOGENOM; CLU_000796_0_0_1; -.
DR InParanoid; L8G6K2; -.
DR OrthoDB; 103295at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45626:SF26; FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED; 1.
DR PANTHER; PTHR45626; TRANSCRIPTION TERMINATION FACTOR 2-RELATED; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2306..2471
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2118..2151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2500 AA; 278690 MW; 82A1A616BA743154 CRC64;
MPRLQARSRN VVTSDSEDDL IVNPPPRRQI WSVISSPKKP LSLSQENSTP AQDGEADDED
DEIDVLTTQS SVRNARANAR TPKSRGISAP KTPLGSSQRN AGNRQTPSKS QTAGNSSQAA
TRLDADVSDS ELIVPGFPEG RRWLHSVRVP VRTPSKQSAI SDFFKPHSLL QKKPAAPTVA
PAVPTAIASD SSPSNPPSDD DPDDAQLSSP VAISPLASRS PSPSGSSAMA NGRPGRAAAI
KGRLLSRVLT ARKDVDTDEA SDVSDFAVSN ESSLGGSSSH VESDESSASP TGESSGADSG
LGSDPPPKRR KRLTDASPPL AKSAPKQVIR KRRVENKDTT FKGADRVLFP ELNNIKNDDD
NEDGDAMEGV QTEASSDTSK RAKAPKKKPT GTQVIKPETY VYKNGLALHE KPISKIEDIF
ADMTDRALTK MSKSKDDKTF LDFLEHMNGR KLRVATMCSG TESPILALNL VSEALKSRGH
NFEIDHKFSA EIVPFKQAYI ERNFSPPIIF RDIKELSIPG AVDATTAYGS KAKIPDNIDI
LITGFSCVDF SGLNSTKRVI EECGESGDTF FAMRDYARIF RPKIIILENV MGAPWLRISD
YMAAIGYACK HHFVDTKNYY VPHTRQRGYM MCIDMYDKVK NDKRTNTEKK LVKDLEFGEY
MKKFGQNAIE TYSRRMDFFK RPASSSVEAF LLDEDDPRVI AGRAEMTKGN AVEGRKRVVD
WTRCQGRHED YRFRMGLGAR RYLTNWEDGG SCTPRDNWWH DWWKAQVERI WDHMEMSYLR
AMVRGYDLEY KFRIIDFSQN IDRSLDTGGS GLTGCVTPTG IPYSSMRGGP LIGIEALALQ
GLPVDSLILT RESQAKLQDL AGNAMSSTVV GAAILSALIA RFDVFERGDG IQEANPAPEI
TQTIDDPKAD SFTTRFDAHV PLSAAAAINA ANQSYRACYC EGRAGVTVAA LQKCKACGHT
TCIKCGVSPK HDYAKFSPDR IAPSEFEQQL KNTLPMKVLL AGISIDDIIK AREDSGVSFS
TADKKAFELS MDHVAQALES ELRFHSLKRT ETWVISYEST YSRLDLIFFL RYAEWRLYAK
PDVDLPANDA LREALQYPIA RMRPTGDDLV TGQWQIWIPK AYKFNASVEG LGVPVPSFHN
VLGIAAAADS FVFPQYEITM PVDAEDYLEV DLSGVYTLQE DCGMSQGSLH VNVNAADPEK
RTFLFHDPDR LGNHEDDTFV FSEDKRRLQH GVVRSLFARV DKKWRQTKFE MSLDGDVEVI
KKGNKKLSLS QARQLDPMTC YVDGQWLDIE NASLDLAHGT ANGQFSRAAE NFSIITSLND
CREAHVVLQC EAALPEGEFS KYRKDHWLEI GELEQKQFFS EYAWLTEKAR TIPGLDTWRE
IENQLATHRC ATCAPAIPNM KWRLDEKRKI VPFEDPTEAA PFEIAMKGRP SPLVTQVCID
DAGIVDLKLA VNPQTLIHRA AAKLLGDDAT SATLQWRLVT NYVAPQKMVF PAFALKNNDA
DTPSSNPPRF KFTLRPEQQR SLYWMVQQEG ANVEPFVEEE VEEASIPLLG WRAEGRASRP
KVIRGGVLAD QVGYGKTVTT LGLIDMQRTS DEKSCKEDVH GLIPIKATLI LVPSQLPDQW
YSEVRKFLPG SYKVTVLKSL ASVDKYSVED FQQADIIIAS WSICEGDNYL FKLAQFAGVL
ELPEKAPARA QSAWYTNAMT KVAENVEVLK SKPSSLKKHI DSQLTDEGKS ATDVEAYVPS
KRLRGQAYQD YKERLQLQKT RLETATDLFG QDALKVDVKT DKKPETKKEF TVKPRKDIFG
LTKLTKTNNY KGMRSPIFEI FRFSRVVVDE YAYVAGEESL TIANLKAAAK WVLSGTPPLQ
DFLDVKCMSR FLGINLGIDD FTTGVMNAQN IKTMTRNMTS SEEFRTFNQK QSFAWHENRH
KLAQRFLDKF VRQNIADIEA INGSVHIMPA ILPAAERAIY LELQQLLAAS DFKMTKGKRA
MENDRMKRIR ELLGQSDSVG EALMKCASHF TLDELHDGLN NAPDACAVIV GIRNKQLDAL
EIDLNRTLRQ AEYLHLSCED PCDQYISLKR QVESNHYGDV DACNAISMAM KEAAKRSSHD
DWEEFYMTQE ERDIVLAAEG RAKPGAKKAK PTKKRKRADS ESDGISSADA PEDTQKLLPL
LPYGRNGNIE YVHTALRDVT NILRKMVVEY VSRKRCLRFF DYVRNLQKHY TNLRLGNEAG
AGCTCSKCEK TGLSPEEISI LSQCGHTACD GCRAKHEKMF YNNLAAKEEC LVVGCSAINK
QWQVIKAPEL GVEDDSTRKG RHYGKKIEDI ISLVKNIPDA EQVLLFVQFT DLLDKIVGAF
RDKGITYLSL DRGDPAKTLT KFQTETGKEK SKVLILNIGD ASAAGSNLTN ANHIIFVSPY
LTDREQTYKA AMTQAVGRAR RYGQTKAVHT YHFLSLKTID VDTFESRNHV ILDHENTTPP
DYMPYSGFAK SMPMDGTPQS EGLGSKWGST VVTKGLLAEE
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