ID L8G9L6_PSED2 Unreviewed; 701 AA.
AC L8G9L6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000256|ARBA:ARBA00020973, ECO:0000256|RuleBase:RU365075};
DE Short=COG complex subunit 6 {ECO:0000256|RuleBase:RU365075};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000256|ARBA:ARBA00031348, ECO:0000256|RuleBase:RU365075};
GN ORFNames=GMDG_04396 {ECO:0000313|EMBL:ELR09920.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR09920.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a component of the peripheral membrane COG complex
CC that is involved in intra-Golgi protein trafficking. COG is located at
CC the cis-Golgi, and regulates tethering of retrograde intra-Golgi
CC vesicles and possibly a number of other membrane trafficking events.
CC {ECO:0000256|ARBA:ARBA00043873}.
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events.
CC {ECO:0000256|RuleBase:RU365075}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex.
CC {ECO:0000256|RuleBase:RU365075}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|RuleBase:RU365075};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|RuleBase:RU365075}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000256|ARBA:ARBA00011023,
CC ECO:0000256|RuleBase:RU365075}.
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DR EMBL; GL573247; ELR09920.1; -; Genomic_DNA.
DR RefSeq; XP_012742817.1; XM_012887363.1.
DR AlphaFoldDB; L8G9L6; -.
DR STRING; 658429.L8G9L6; -.
DR VEuPathDB; FungiDB:GMDG_04396; -.
DR HOGENOM; CLU_011361_1_0_1; -.
DR InParanoid; L8G9L6; -.
DR OrthoDB; 276556at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR InterPro; IPR048369; COG6_C.
DR InterPro; IPR048368; COG6_N.
DR PANTHER; PTHR21506; COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6; 1.
DR PANTHER; PTHR21506:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6; 1.
DR Pfam; PF20653; COG6_C; 1.
DR Pfam; PF06419; COG6_N; 1.
DR SMART; SM01087; COG6; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU365075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365075};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365075};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365075}.
FT DOMAIN 60..173
FT /note="Conserved oligomeric complex COG6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06419"
FT DOMAIN 204..700
FT /note="Conserved Oligomeric Golgi complex subunit 6 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20653"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 78936 MW; 602DA0EF46BF4DC6 CRC64;
MAAGYFPTKG QSPVDGRAAS PALSSTAQTP IRSNALSSKV NSVLSASYAD LEIRDALQLL
DERGVENTVE TRRQLRLDIQ KDVIDSNGLV IKEFGHVAEQ LRRIGQSIAS LNQGCEEMRR
HITAAHQETA PVLDEASDLM ARKKDVEMKQ KLLQAFNTHF VMSDDDIATV TSTAEPVNDE
FFIVLNRAKQ IQVDCEILLS SENQRLGLEI MEQTTTNLNG AFQKLYRWIQ REFKSLNLEN
PQINASIRRA LRVLAERPKL FQNCLDFFAE ARENILSDSF YTALTGLSVT GDEDKTVKPL
ELVAHDPLRY VGDMLAWTHS ATVSEREALE VLFISDGNEI AKGIQAGRDS EPWNKYIRDE
EADTVFDGQK ALNDLVDRDV AGVARVLKQR IEQVIQSHDE TILVYKISNL VNFYRVMLTK
ILGEDSALLS TLQGLEDFGL RHFRVLMRDH IASLQTETQQ PPADLGLPIF LQEGLKQLTE
IMKTYDTSFT SAKSREENFK TVLDDAFEPY IRGIETMAKD MEMPTNSIFI INCFLSCKTT
LESYQFTSDR AEELGKTVEQ HSIDLIEYQY AFFLQSSGLQ RLVDTLQSMG NEPDLKKLVS
TEAFQPQALK DASQILDDFL PSALMDALDN LRQLQSSRLA REITEEAADR FCEDFEVVEE
RITQADGVVE RSEDGGEDGE EILGLRALFP RTSGEIRVLL T
//
