ID L8GAA3_PSED2 Unreviewed; 201 AA.
AC L8GAA3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000256|ARBA:ARBA00033774};
DE AltName: Full=PX domain-containing protein YPT35 {ECO:0000256|ARBA:ARBA00033785};
GN ORFNames=GMDG_00775 {ECO:0000313|EMBL:ELR10017.1};
OS Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS white-nose syndrome fungus) (Geomyces destructans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR10017.1, ECO:0000313|Proteomes:UP000011064};
RN [1] {ECO:0000313|Proteomes:UP000011064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Geomyces destructans 20631-21.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC vacuolar membranes. {ECO:0000256|ARBA:ARBA00033728}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004148};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004148}.
CC -!- SIMILARITY: Belongs to the YPT35 family.
CC {ECO:0000256|ARBA:ARBA00007426}.
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DR EMBL; GL573176; ELR10017.1; -; Genomic_DNA.
DR RefSeq; XP_012739168.1; XM_012883714.1.
DR AlphaFoldDB; L8GAA3; -.
DR STRING; 658429.L8GAA3; -.
DR VEuPathDB; FungiDB:GMDG_00775; -.
DR HOGENOM; CLU_070610_1_1_1; -.
DR InParanoid; L8GAA3; -.
DR OrthoDB; 2041724at2759; -.
DR Proteomes; UP000011064; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR CDD; cd07280; PX_YPT35; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037917; Ypt35_PX.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR PANTHER; PTHR45949:SF2; SORTING NEXIN-4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT DOMAIN 91..201
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 19..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 201 AA; 22395 MW; 9D443D81C721A1A4 CRC64;
MDVAGDRRLL IHGFESVDHG DDESRTFPAS ATPLPLTTET SSPITSPPYW VQSHKRSASQ
VSVDSVLHGG ITLHDNTTGY SDSNDACWAR SVTIDEHAVV NGNRTGIGAF VVWNITIETL
SGSKIHLRKR YSEFDTLRRN LLMTFPLSEA SMPPLPPKGV VSKFRPKFLD QRRIGLQYFL
NCILLNPEFS SSPVMKDFLF T
//
