ID   L8GAV5_PSED2            Unreviewed;       723 AA.
AC   L8GAV5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS51873};
GN   ORFNames=GMDG_03721 {ECO:0000313|EMBL:ELR09141.1};
OS   Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat
OS   white-nose syndrome fungus) (Geomyces destructans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=658429 {ECO:0000313|EMBL:ELR09141.1, ECO:0000313|Proteomes:UP000011064};
RN   [1] {ECO:0000313|Proteomes:UP000011064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4855 / 20631-21 {ECO:0000313|Proteomes:UP000011064};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C.A., Blehert D.S., Lorch J.M., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA   Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Geomyces destructans 20631-21.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL573230; ELR09141.1; -; Genomic_DNA.
DR   RefSeq; XP_012742138.1; XM_012886684.1.
DR   AlphaFoldDB; L8GAV5; -.
DR   STRING; 658429.L8GAV5; -.
DR   VEuPathDB; FungiDB:GMDG_03721; -.
DR   HOGENOM; CLU_401765_0_0_1; -.
DR   InParanoid; L8GAV5; -.
DR   OrthoDB; 251172at2759; -.
DR   Proteomes; UP000011064; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20335; BRcat_RBR; 1.
DR   CDD; cd22584; Rcat_RBR_unk; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR11685:SF457; TRANSLATION TERMINATION INHIBITOR PROTEIN ITT1; 1.
DR   Pfam; PF01485; IBR; 1.
DR   SMART; SM00647; IBR; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51873; TRIAD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011064};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          236..441
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   REGION          56..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..37
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          465..523
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        79..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  81332 MW;  174368A4A5D9FE1D CRC64;
     MEQLHALFEY EARLERQQQL AEERSRLERQ RVAAVENSFQ QQQERHLLAI LRQGSERELP
     VENSPGHRGN VGAPANMSKG KGKNTQESPE NVPNVDSQPS VVAPPLQTQG YISTSAPGKQ
     VAPAKTPAAP MVSPPVREEV SFAAREEPPA FQKSRSVSPK SPPAYAESSS AAAARPPAAM
     KGSPTSAGCP PADTGGSSSR KWSLRLLRPY VTTVFKPGGR SGRGILSRRT KESTSQTGEC
     VSCMDDFCVQ EMVPLTCHAY CSPCFTLLIE TSISTETSWP PKCCLNVIPR SLIMSNLHGK
     LKTRYETMLE ERSIAIEDRV YCSKPSCGSW IPHHKIDKPL ILARCARCRH KTCMICRGSY
     HSNGECPEDP SLRETIQCAL NAGWRRCYKC NALVEHAQGC SHMTCNCKAQ FCYTCGLKWK
     TCTCTEIELE AYLISADWRR ETAASQAQIR QAAYAALDRE VRADQTEHAN ELRETLNLLE
     NFEERTPAQR AAEERAFAVV AEREAEQDRS RDFEVKLQRL REEMDLVHSI QQIANFDRFE
     TENEALADAA KEELAHIDDY FHALSLEEKD GMVGEYLILL RRAGMELTDE MMNGAGKKVD
     MSKAIDEQIA HELRPSILKS PAELTRVKEE TARYIEFFKR QGKEPTEHLI NVAHRGAARR
     TVKMHQLARE ARHDQQSDKI NARLEAEQER LRAGHQTDMK WFEEIATVRD ALLVQMTVDE
     YSL
//