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Database: UniProt
Entry: L8GQL7_ACACA
LinkDB: L8GQL7_ACACA
Original site: L8GQL7_ACACA 
ID   L8GQL7_ACACA            Unreviewed;       999 AA.
AC   L8GQL7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   23-MAY-2018, entry version 30.
DE   SubName: Full=Twocomponent hybrid sensor and regulator kinase {ECO:0000313|EMBL:ELR14948.1};
GN   ORFNames=ACA1_051910 {ECO:0000313|EMBL:ELR14948.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR14948.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR14948.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR14948.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
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DR   EMBL; KB008040; ELR14948.1; -; Genomic_DNA.
DR   RefSeq; XP_004336961.1; XM_004336913.1.
DR   EnsemblProtists; ELR14948; ELR14948; ACA1_051910.
DR   GeneID; 14915550; -.
DR   KEGG; acan:ACA1_051910; -.
DR   EuPathDB; AmoebaDB:ACA1_051910; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00156; REC; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   Kinase {ECO:0000313|EMBL:ELR14948.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083};
KW   Transferase {ECO:0000313|EMBL:ELR14948.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     33     57       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     69     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    105    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    134    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      450    678       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   DOMAIN      854    975       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   COILED      163    183       {ECO:0000256|SAM:Coils}.
FT   MOD_RES     902    902       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   999 AA;  110626 MW;  8A27CD7F8AF232CB CRC64;
     MEDEGGGSHD VEAHPLGEEP PADRWEYLSS PKWGYIISAA LPSALLLFFV AIIFGVGSGR
     HGSPTVTFLL SYSDALIALS YFFIPGAIFT VVLKRGDIDR NVWTVWMFGA FIVCCGLTHL
     VSALCIWFNL GMKVVTAGIS YATAIAVYKL IPLALAIPSP IQLEKEINER KDAQRKLQTQ
     YKRSVVLSRV TKEIRRSLKL QDISNATAAQ CIDVFDADVC SVYRCDPNPS HGLETSPLEG
     TSPDDTDHRA VPEGKGKDKE GNDVPNNRGQ THCQPYKWRL LSEYDRWAPD SPKTDKQACS
     DAEVPMLHLL PGLPEGNTAM VIDFERKEQL TCAPAKLSGV ALDESLVNYY RQRRIRSLLC
     VSVPYQRDSY AVIVLQLRHG STGRAADDWH LDDIILLQEV ITQVAIGLEH AYLLCQANKG
     RKLAWRNLAL ERAKEKAEQN SQAKSEFLAV VSHEIRTPMN AICGMTKVLK GSHISREQRD
     CVQIISSSAK ALLSLLNNIL DFSKIEAGKT EIHQCPFDLY KCIRNLMGLM SNYTTGRHQK
     VTLSTLIDPT VPSFVIGDKQ HLRQVLINLL SNALKFTPEG SITLRVLTNS TWETSDKEKY
     AQLHFEVTDT GIGIPHEKQS RLFRPFSQVD SSATRKYEGT GLGLVISKRL CELMGGHMEV
     HSEEGKGSMF TFTIRVKLQG AVPDYDKCCQ LEKNDRRNDA RQMAEQILPE LQMRTALGAL
     DAAEAQPGAI ARPNSPVTNE AAASSSSSSS PSAAPAASDS TTLAPAHSSV FLYNNLNEAA
     RRHIHPQHTH SLPTRLRPIT PLPYTPMDSP RLPGTQHYPP PHPEPATGGP RRYSMAVTPK
     DPVRHSDQYP VIDRILLAED NTINQKVACK LLSRIGHTQV AAVDAVREAN AEGKPFSVIL
     MDLHMPEMDG ITASRMIKQE EQERSGTTRP PPYIIACTAD LQYGTRKECR QAGMDGYLPK
     PIKLKELSRV LVHAQMTMLQ QKTGLLDDQT AQEPDTASE
//
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