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Database: UniProt
Entry: L8GU40_ACACA
LinkDB: L8GU40_ACACA
Original site: L8GU40_ACACA 
ID   L8GU40_ACACA            Unreviewed;       667 AA.
AC   L8GU40;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   03-JUL-2019, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ELR16123.1};
GN   ORFNames=ACA1_177110 {ECO:0000313|EMBL:ELR16123.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR16123.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR16123.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR16123.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
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DR   EMBL; KB008006; ELR16123.1; -; Genomic_DNA.
DR   RefSeq; XP_004338136.1; XM_004338088.1.
DR   EnsemblProtists; ELR16123; ELR16123; ACA1_177110.
DR   GeneID; 14916812; -.
DR   KEGG; acan:ACA1_177110; -.
DR   EuPathDB; AmoebaDB:ACA1_177110; -.
DR   OrthoDB; 798314at2759; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; -; 3.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 2.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    667       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003990088.
FT   DOMAIN       29    170       GMC_OxRdtase_N. {ECO:0000259|Pfam:
FT                                PF00732}.
FT   DOMAIN      277    372       GMC_OxRdtase_N. {ECO:0000259|Pfam:
FT                                PF00732}.
FT   DOMAIN      575    659       GMC_oxred_C. {ECO:0000259|Pfam:PF05199}.
FT   BINDING     288    288       FAD; via amide nitrogen and carbonyl
FT                                oxygen. {ECO:0000256|PIRSR:PIRSR000137-
FT                                2}.
SQ   SEQUENCE   667 AA;  71449 MW;  0B652786C92E46E5 CRC64;
     MNKLLLSFFA LVVMMLALAQ AGTDIRRSYD YVIAGGGGAG AVLAGKLARS GARVLLLEAG
     DNTQYDPNIY NPLGTFGGFN SRSNNIGLSS DTTYVWPNRV AGDPGRYGLA DAPNSGKGLG
     GGTSVNTMIL AHGGRWMYDL PANGWPSSWS YNQMKPYYAE VKAALQPHRE TRKPPTSQNF
     LKAVRRVADV QYAAGGLDYL VNAANYAAGP NVEDPSESAP QLDYNDLDGV NSVGAFSQYQ
     FFVNKLANGT FVRKYAANTF LGPDCLDREG HGVSPACPHL SVLTGAYVSR VIFDTDRRWW
     SQPVATGIEF YQDGESKVVL ARKGVILAAG AFQTPAVLQR SGYGDADYLA SIGVEPIVYN
     NTQVGRNLKN HYAPFMIANV TAGDRAELTA FMSGSALMAG NMGFNGGAFL GFHKLDPNRP
     AGSNTTSVRR AQLLYSTSGM FFPRSVGAAY NIGSTNETVV LGIDDLRFDG TGYVQIGTKN
     AFDFPKVFYS SFVDYSNPAL TGQAFWDAAR VGASATISGL LIYHMGYEIY AQMNQVLADE
     GSSVRFAMAY PTASDLELLD QGLATHGADW WKHLFPDRLA GTASSDPAFS AALKRLTYQL
     RMAARIDSHQ VSTCKMGQVV DQRLNVIGVS NLKIADASVL AAQVGGGNAF TANVIGARAA
     DFVLADF
//
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