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Database: UniProt
Entry: L8GUM0_ACACA
LinkDB: L8GUM0_ACACA
Original site: L8GUM0_ACACA 
ID   L8GUM0_ACACA            Unreviewed;       597 AA.
AC   L8GUM0;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   11-DEC-2019, entry version 37.
DE   SubName: Full=Bbox zinc finger domain containing protein {ECO:0000313|EMBL:ELR15801.1};
GN   ORFNames=ACA1_078640 {ECO:0000313|EMBL:ELR15801.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR15801.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR15801.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR15801.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I., Finkler A.,
RA   Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T., Chu J.S.,
RA   Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A., Lorenzo-Morales J.,
RA   Bateman A., Chiu C.H., Tang P., Hegemann P., Fromm H., Raoult D., Greub G.,
RA   Miranda-Saavedra D., Chen N., Nash P., Ginger M.L., Horn M., Schaap P.,
RA   Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
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DR   EMBL; KB008022; ELR15801.1; -; Genomic_DNA.
DR   RefSeq; XP_004337814.1; XM_004337766.1.
DR   EnsemblProtists; ELR15801; ELR15801; ACA1_078640.
DR   GeneID; 14916435; -.
DR   KEGG; acan:ACA1_078640; -.
DR   EuPathDB; AmoebaDB:ACA1_078640; -.
DR   KO; K12035; -.
DR   OrthoDB; 489543at2759; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00021; BBOX; 1.
DR   Gene3D; 2.120.10.30; -; 4.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF01436; NHL; 4.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00336; BBOX; 2.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 4.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|SAAS:SAAS00139427};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083};
KW   Zinc {ECO:0000256|SAAS:SAAS00139522};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024,
KW   ECO:0000256|SAAS:SAAS00139444}.
FT   DOMAIN          24..86
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          190..227
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   REPEAT          416..455
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          460..503
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          529..572
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          574..597
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ   SEQUENCE   597 AA;  63642 MW;  46DAF7C521838806 CRC64;
     MNHHPPLATS AAAAEEDKDD VGTCSVCFLA FSASEADRVP RLLKCGHSFC TACLSHLLAS
     PTPTPTANSE AELEEATWPL RCPKCRTETR VLLVDGEVAA GVKGLPRNFD LIDLLSSALR
     QPRPTGETCA MAALKCANCS QPAAEKFCEQ CGGAHLCVSC DHQIHAFPAL RSHRRVASTD
     APHAPGPSTC ERHRGKKAKM WCEHDGVAVC TMCLIVGPHK GHDAVTIEEA VERVREAALV
     DLAQVEAAMG EVEAAVERQA AHEAGEQESA REARAAIKQH FDRMREAVAQ RERALGAELD
     EWEHTRAEAA AKRRAELAGA QTRLAAAGKA LQQQLQLQHG GLGRSATSSD SAPCQEARTA
     AAAVTGTQAS SSSIAFTSED TWVQVVGSSG RLERRVAATD AGGVVRDYAA MTAAQRTFGS
     GAQLRCPWGV AVDAATGHIV VADFDGRRVH VWRSDDGSCV RSFLNHGSGP AQFRCPRGVA
     VDEEGHIIVA DCFNHRVQVW RANDGTCLRI FGSEGNNRVH VWRTDGSFIC TFGSAGRGYG
     QFMNPMGVAV DTTTGYVVVA DYGNHRVQFN GPAGVAVDAA TGNIIVADSS NKRVQVW
//
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