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Database: UniProt
Entry: L8H6F5_ACACA
LinkDB: L8H6F5_ACACA
Original site: L8H6F5_ACACA 
ID   L8H6F5_ACACA            Unreviewed;      1025 AA.
AC   L8H6F5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   07-NOV-2018, entry version 17.
DE   SubName: Full=RFX DNA-binding domain containing protein {ECO:0000313|EMBL:ELR20822.1};
GN   ORFNames=ACA1_277400 {ECO:0000313|EMBL:ELR20822.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR20822.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR20822.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR20822.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
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DR   EMBL; KB007908; ELR20822.1; -; Genomic_DNA.
DR   RefSeq; XP_004344565.1; XM_004344515.1.
DR   ProteinModelPortal; L8H6F5; -.
DR   EnsemblProtists; ELR20822; ELR20822; ACA1_277400.
DR   GeneID; 14921692; -.
DR   KEGG; acan:ACA1_277400; -.
DR   EuPathDB; AmoebaDB:ACA1_277400; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619; PTHR12619; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   DNA-binding {ECO:0000313|EMBL:ELR20822.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083}.
FT   DOMAIN       70    145       RFX-type winged-helix.
FT                                {ECO:0000259|PROSITE:PS51526}.
SQ   SEQUENCE   1025 AA;  112413 MW;  00D80BB61C2DA344 CRC64;
     METVDHNRAL ATGRGAGDAK EEGEDESSEG EEEEGEGAAD LHTQAPDQPT KRKRKKSKKK
     LERERTLPII VQWLQDTYEE KEGKTVGRYQ VYDDYIEFCA RAGHLPTNNA ALGKIFKRVF
     PNVGWRRLGK RGESKMHYAN IRKRKGKVEQ AALQASSFLS SSSSSSLLTL TSGSGGIKAE
     PDEREHGYES KARAVARIKE DNDEFGDDED DDSDGDDNEY SDTGSSSNNN GGGDREKGRG
     SIMELERELE LGGVEGGDAF IELLGESAVA ARHDRFAGFG GGDGSVFGGA VPMAQHRTKF
     PGRERERRWR RRDHLTTSRE EMEEPRGLFF SSGVPSPSSS PSSSSFQGSA MMAAPPGNLS
     IWNADAHLDL MMAVRYYRDR FRKISWSLIP INPMSLKMRL LNYLFCTEEG QLERSSLSLS
     ACVMISIASF GAGHFDVAEE FFHKAREHLS YVFDSSDYDV ASALVPLAWL TTFFSPTPEE
     GRNRQIYFCT IGTKICEQVG ALNDETHWAL LSTLHVKSME SASDAITKTR AYPPYQKQWK
     NTRLQRGRIS GTYDQTGDIF GSVFALSVPL IRGFSLPPEE ERRIKHGLMV QLGRLREAEQ
     GLVHAQDQQV RDMMAAYYFA MRTFINVLLE NSRQIETARE LVRTLMLADR PIMAVVLHEL
     SSNKFLLIRT AVQVLVRYKE YKAIKLLMEA IYPFTSRFPW MHAIYVLTQQ AVQESFHGLR
     IASCSPPLPL PAQAQSLSSS AASYPPLSAL VSASAVPPPP AFYLPSDSSP LHSAPHHQHP
     HSHPHQPQPP HYQPRPHPPQ PQPHLHAYGH HTPEPMQRAS PSPQLPDRRP SSASYSYIFY
     ADPSSSLSSS AAASATDPAY FPLSSSSSAS TSPTVAPTAP FQSATGSASY PTISPELSPF
     PSSSSRATAT FRPITSDQPG TTHPSGSPSL ARALDDMSLL ESLLSSSPSS SSPSGSSLSF
     SATSSTSTSM LAAASYEPPP LLAQPWEQEM HLYHPQGPPP HAHTGGGGQP AVPQLDPAVP
     RHGSA
//
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