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Database: UniProt
Entry: L8H893_ACACA
LinkDB: L8H893_ACACA
Original site: L8H893_ACACA 
ID   L8H893_ACACA            Unreviewed;       360 AA.
AC   L8H893;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   31-JUL-2019, entry version 18.
DE   RecName: Full=TYR_PHOSPHATASE_2 domain-containing protein {ECO:0000259|PROSITE:PS50056};
GN   ORFNames=ACA1_183190 {ECO:0000313|EMBL:ELR21385.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR21385.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR21385.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR21385.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
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DR   EMBL; KB007904; ELR21385.1; -; Genomic_DNA.
DR   RefSeq; XP_004345929.1; XM_004345879.1.
DR   EnsemblProtists; ELR21385; ELR21385; ACA1_183190.
DR   GeneID; 14922277; -.
DR   KEGG; acan:ACA1_183190; -.
DR   EuPathDB; AmoebaDB:ACA1_183190; -.
DR   OrthoDB; 1539111at2759; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR022778; CDKN3.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF05706; CDKN3; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083}.
FT   DOMAIN      272    326       TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE:
FT                                PS50056}.
FT   REGION        1     34       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      129    149       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   360 AA;  39026 MW;  7D7B9CE66B110B3B CRC64;
     MLGDGDDVAA QDESGGEDEY GGYAPLGAGD DDNIDDAQQA AAAVQGLEGL EVHAQMARIG
     VALYVSEEEQ QRRRAEAMAA FDARYQEEVQ VAAAAAATNE RFPAFSADHI NDIKEAMRGI
     SLPVDAPAWA QGGGNKKGGK EKGGGGTAGG AVRHQQLLAK LPLALPTDHL TRDMSGPTPY
     SNWVVRGCLL VGAYPLKPYM TEAILKQGTR PLHWVTVFVC LMEESEFGKH GKHYFDVAKS
     MLDSRPSDFV QKSQELRYVH HPIPDRMIGS DDATLVLVEK ILAFLRAGEM VYIHCYGGHG
     RTGIFASVLL GRIHGIDAEK ALQLCKLYHD CRPDVEGISA KSVPSPQTHD QRAQVVRLLR
//
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