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Database: UniProt
Entry: L8HHZ9_ACACA
LinkDB: L8HHZ9_ACACA
Original site: L8HHZ9_ACACA 
ID   L8HHZ9_ACACA            Unreviewed;       774 AA.
AC   L8HHZ9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   13-NOV-2019, entry version 36.
DE   SubName: Full=Protein kinase domain containing protein {ECO:0000313|EMBL:ELR24328.1};
GN   ORFNames=ACA1_356810 {ECO:0000313|EMBL:ELR24328.1};
OS   Acanthamoeba castellanii str. Neff.
OC   Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC   Acanthamoebidae; Acanthamoeba.
OX   NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR24328.1, ECO:0000313|Proteomes:UP000011083};
RN   [1] {ECO:0000313|EMBL:ELR24328.1, ECO:0000313|Proteomes:UP000011083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Neff {ECO:0000313|EMBL:ELR24328.1,
RC   ECO:0000313|Proteomes:UP000011083};
RX   PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA   Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA   Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA   Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I.,
RA   Finkler A., Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T.,
RA   Chu J.S., Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A.,
RA   Lorenzo-Morales J., Bateman A., Chiu C.H., Tang P., Hegemann P.,
RA   Fromm H., Raoult D., Greub G., Miranda-Saavedra D., Chen N., Nash P.,
RA   Ginger M.L., Horn M., Schaap P., Caler L., Loftus B.;
RT   "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT   transfer and early evolution of tyrosine kinase signaling.";
RL   Genome Biol. 14:R11-R11(2013).
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DR   EMBL; KB007831; ELR24328.1; -; Genomic_DNA.
DR   RefSeq; XP_004354025.1; XM_004353973.1.
DR   EnsemblProtists; ELR24328; ELR24328; ACA1_356810.
DR   GeneID; 14925349; -.
DR   KEGG; acan:ACA1_356810; -.
DR   EuPathDB; AmoebaDB:ACA1_356810; -.
DR   OrthoDB; 738003at2759; -.
DR   Proteomes; UP000011083; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00752238};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011083};
KW   Kinase {ECO:0000256|SAAS:SAAS00442532, ECO:0000313|EMBL:ELR24328.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00753232};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011083};
KW   Transferase {ECO:0000256|SAAS:SAAS00442167}.
FT   DOMAIN      178    443       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      482    574       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      603    645       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    482    516       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    557    571       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    604    645       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   774 AA;  85176 MW;  BCBAE24499F555FE CRC64;
     MRKQPGDMPE CIEFGRNYQF DFIPKGFFAK IMVRLLSLDL QATCYWRYGM VAVVDNDKIA
     LEWSERSKVI KISLRTSRDK LNAGNTNRSL FSLAVGCADS LVADWYNLKT KVMVPCVHCL
     EWGKKRPRMF DLEECRLAVM RGESHAYCSP VIAVRYDHLV PDIALTDLAQ NKINYASLDI
     KEKIGEGSFS VVYKGIYNNE EVAIKRLKFN DEKIRENRLL KAFDEFRNEV FLMSGLKHPN
     IITMTGFCTK PSYCIVTEFV SGGTLLELLQ NEESVIDWSL RLRLAKDIAK GVAFLHSCSP
     PIVHRDLKSP NVLLVSMDDD APVLAKIADF GLSAAMMQSA MGRKVDCPVW LAPEIMRNQE
     YTTKADVYSM GIILWELLTK QQKLFSEVKF MIQLEDRILT GERPPIPDDC VPAYRQLIEE
     CWNHEPEKRP NMDDIVARLQ ALLAELCPGV ADYDKAVLHR ESEANGAVDG DRTEGILSAI
     AHSSARPSSS LPSDRQPTVS PSSSSSLSSS TALGLHTSHP GVMRYQPAAS GTSSSPLSLS
     SPPAPTTPRA PTAASAAAVS GWTSGSPSPQ AAAFDPASVP AAASLHFPYF ALQNPAAFFP
     RFHHHPTTTS SPSITTSPAD SGSTSPSSSS SSTSSSTPRS TSTSPVLSAY PYVSSPYPFP
     FPMPSPYLPP FPPPFPAGTH AHALALARED PLHWTSDRVG EWLDHRDVAC GQHRAALTKF
     NGRALIRLTE EQVDKLLPAS DKADAILLFQ HIQDLRDLSL YCSIHQALTS STSP
//
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