ID L8IU05_9CETA Unreviewed; 539 AA.
AC L8IU05;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=FERM domain-containing protein 5 {ECO:0000313|EMBL:ELR58647.1};
DE Flags: Fragment;
GN ORFNames=M91_01187 {ECO:0000313|EMBL:ELR58647.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR58647.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR58647.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH880816; ELR58647.1; -; Genomic_DNA.
DR AlphaFoldDB; L8IU05; -.
DR STRING; 72004.ENSBMUP00000027659; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13192; FERM_C_FRMD3_FRMD5; 1.
DR CDD; cd17102; FERM_F1_FRMD3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF5; FERM DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 466..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..267
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 313..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 539
FT /evidence="ECO:0000313|EMBL:ELR58647.1"
SQ SEQUENCE 539 AA; 61455 MW; 959133ADD5D1B27D CRC64;
SLQRDAKGQY LFDLLCHHLN LLEKDYFGIR FVDPDKQRHW LEFTKSVVKQ LRSQPPFTMC
FRVKFYPADP AALKEEITRY LVFLQIKRDL YHGRLLCKTS DAALLAAYIL QAEIGDYDPG
KHPEGYSSKF QFFPKHSEKL ERKIAEIHKT ELSGQTPATS ELNFLRKAQT LETYGVDPHP
CKDVSGNAAF LAFTPFGFVV LQGNKRVHFI KWNEVTKLKF EGKTFYLYVS QKEEKKIILT
YFAPTPEACK HLWKCGIENQ AFYKLEKSSQ VRTVSSSNLF FKGSRFRYSG RVAKEVMESS
AKIKREPPEI HRAGMVPSRS CPSITHGPRL SSVPRTRRRA VHISIMEGLE SLRDSAHSTP
VRASSHGDTF LPHARSSRAD SNERVAVIAD EAYSPADSVL PTPVAEHSLE LMLLSRQING
ATCSIEEEKE SEASTPTAAE LEALGGELRA LCQGHGRPEE EQVNKFVLSV LRLLLVTMGL
LFVLLLLLII LTESDLDIAF FRDIRQTPEF EQFHYQYFCP LRRWFACKIR SVVSLLIDT
//
