ID L8IU73_9CETA Unreviewed; 1011 AA.
AC L8IU73;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=UPF0577 protein KIAA1324 {ECO:0000313|EMBL:ELR59573.1};
GN ORFNames=M91_01632 {ECO:0000313|EMBL:ELR59573.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR59573.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR59573.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the ELAPOR family.
CC {ECO:0000256|ARBA:ARBA00007627}.
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DR EMBL; JH880704; ELR59573.1; -; Genomic_DNA.
DR AlphaFoldDB; L8IU73; -.
DR STRING; 72004.ENSBMUP00000005003; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR039181; EIG121-like.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR22727:SF13; ENDOSOME_LYSOSOME-ASSOCIATED APOPTOSIS AND AUTOPHAGY REGULATOR 1; 1.
DR PANTHER; PTHR22727; PROTEIN CBG13728; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..1011
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003993058"
FT TRANSMEM 905..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 654..856
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 990..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 110952 MW; 9C0544B2386F93C9 CRC64;
MAEPGHSLHP SARGRGRTEP RTFRLLRLLL WVGTAFQVTQ GAGLELHACK ESEYHYEYTA
CDSTGSRWRV AVPHTPGLCT SLPDPVKGTE CSFSCKAGEF LDMKDQSCKP CAEGRYSLGT
GIRFDEWDEL PHGFASLSTN MEIEDSTLES TENCTSSKWV PLGDYIASNT DECTATLMYA
VNLKQSGTVN FEYYYPDSSI IFEFFNDQCQ PNADDSRWMK TTEKGWEFHS VELNRGNNVL
YWRTTAFSVW SKISKPVLVR NIAITGVAYT SECFPCKPGT YADQQGSSSC KLCPANFYSN
KGETSCHQCD PDKYSEKGSS TCKARPACTD KDYFYTHTAC DANGETQLMY KWAQPKICGE
DLEGAVKLPA SGLKTGCPPC NPGFFKTNSS TCEPCPYGSY SNGSDCSHCP AGTEPAVGFE
YKWWNTLPTN METTVLSGIN FEYKGMTGWE VAGDHIYSAV GASDNDFMIL TLVVPGFRPP
QSVMADTENK EVARITFVFE TICSVNCELY FMVGVNSRTN SPVETWKGSK GKQSYTYIIE
ENATMSFTWA FQRTTFHETG RKYTSDVAKI YSINVTNVMD GVASYCRPCA LEASDMGSSC
TSCLAGHYID RDSGTCHSCP PNTILKAHQP YGAQACMPCG PGTKSNKIHS LCYNDCTFSV
STSTRTFEYN FLALEKTVSL AGGPSFTSKG LKYFHHFTLS LCGNQGRKMS VCTDNVTDLR
IPEGESGFSK PITAYVCQAI IIPPEVTGYK AGVSSQPVSL ADRLIGVTTD MTLDGITSPA
ELFHPESLGI PDVIFFYRSN DVTQSCSSGR STTIRVRCSP LKPAPGSLSL PSKCSDGTCD
GCNFHFLWES VAACPLCSTA DYHAIVSSCV AGIQKTTYVW REPKLCSGGI SLPEQRVTIC
KTIDFWLKVG ISAGTCTAIL LTVLTCYFWK KNQKLEYKYS KLVMNATLKD CDLPAADSCA
IMEGEDVEDD LIFTSKKSLF GKIKSFTSKR TPDGFDSVPL KTSSGGPDMD L
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