ID L8JEZ8_9GAMM Unreviewed; 1042 AA.
AC L8JEZ8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:ELR66793.1};
GN ORFNames=C942_04491 {ECO:0000313|EMBL:ELR66793.1};
OS Photobacterium marinum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=1056511 {ECO:0000313|EMBL:ELR66793.1, ECO:0000313|Proteomes:UP000011134};
RN [1] {ECO:0000313|EMBL:ELR66793.1, ECO:0000313|Proteomes:UP000011134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK15 {ECO:0000313|EMBL:ELR66793.1,
RC ECO:0000313|Proteomes:UP000011134};
RA Khatri I., Vaidya B., Srinivas T.N.R., Subramanian S., Pinnaka A.;
RT "Genome Assembly of Photobacterium sp. AK15.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELR66793.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMZO01000006; ELR66793.1; -; Genomic_DNA.
DR RefSeq; WP_007463768.1; NZ_AMZO01000006.1.
DR AlphaFoldDB; L8JEZ8; -.
DR PATRIC; fig|1056511.3.peg.1320; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000011134; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1042 AA; 113982 MW; 0F3DD791A3B743AF CRC64;
MIGAIIRWSI SNRFLVLIAT LFLTLGGLYS VTKTPVDALP DLSDVQVIIK TSYPGQAPQV
VEDQVTYPLT TAMLAVPGAE TVRGYSFFGD SYVYIIFNDD TDMYWARSRV LEYLSQVAPN
LPSDAKPTLG PDATGVGWIY SYVLQDKTGQ HDLAELRSLQ DWFLKYELQT VDGVSEVATV
GGMVKQYQVQ IDPVKLRAYD LTLQQVNNAI KNGNQETGAS VIEVAEAEHM VRTTGYLTGI
EDIKSLPLKV TERGTPLLLG DISDINLGPQ MRRGISEFNG EGEAVGGVIV MRFGENASEV
IDNVKNKLEE LQRSLPDGVE IVATYDRSTL INAAVENLWS KLAEEFIVVA IVCALFLFHI
RSSLVIALSL PVGILVAFVV MHWQGINANI MSLGGIAIAI GAMVDGAIVM IENVHKHIER
TPLTDKNRWQ VIGKAAEEVG APLFFSLLII TLSFVPVFAL EGQEGKMFSP LAFTKTYAMA
AAAGLAITLV PVLMGYFIRG KVLPEHKNPV NKALVALYRP LLSISLKYPK AMIVVALALM
ASAYYPTSKL GSEFIPPLDE GDLMYMPTTY PGISIGKARE LLQQTNKLIK TVPEVETVWG
KIGRAETATD PAPLTMIETV IQLKPQDQWR EGVTTESLRK EFDDLVQLPG LTNAWVMPIK
TRIDMLATGI KTPIGIKIAG PDLKEIEKIG ADLEPILSQI PGTASVYAER VAGGRYVTID
IKRRAAARYG LSIKDVQQVI STAVGGMTVG ETVEGLERYP INVRYPQDYR DSVIKLQNLP
LVTPGGARIA LADVADIRYE DGPPMIKTEN ARPNGWVFVD IDGRDLGSYV TEAQQIVAEQ
LQLPSGYSLA WSGQYEYMER AKARLSVVVP ITISIIMLLL YFSFRRVGEV LIIMATLPLA
MVGGLWLMHI LDYNFSIAVG VGFIALAGVA VEIGVIMLVY LNQAWHDKKH EATENHYALS
AEDLSNAIRE GAGLRVRPVM MTVLTVIIGL IPIMYGEGTG SEVMQRIAAP MIGGMASALL
LTLLVLPAIF KLWKQKDIAS PL
//
