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Database: UniProt
Entry: L8LH16_9CHRO
LinkDB: L8LH16_9CHRO
Original site: L8LH16_9CHRO 
ID   L8LH16_9CHRO            Unreviewed;       432 AA.
AC   L8LH16;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   10-APR-2019, entry version 29.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=GLO73106DRAFT_00006370 {ECO:0000313|EMBL:ELR96838.1};
OS   Gloeocapsa sp. PCC 73106.
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Chroococcaceae; Gloeocapsa.
OX   NCBI_TaxID=102232 {ECO:0000313|EMBL:ELR96838.1, ECO:0000313|Proteomes:UP000011180};
RN   [1] {ECO:0000313|EMBL:ELR96838.1, ECO:0000313|Proteomes:UP000011180}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 73106 {ECO:0000313|EMBL:ELR96838.1,
RC   ECO:0000313|Proteomes:UP000011180};
RX   PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA   Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E.,
RA   Calteau A., Cai F., Tandeau de Marsac N., Rippka R., Herdman M.,
RA   Sivonen K., Coursin T., Laurent T., Goodwin L., Nolan M.,
RA   Davenport K.W., Han C.S., Rubin E.M., Eisen J.A., Woyke T., Gugger M.,
RA   Kerfeld C.A.;
RT   "Improving the coverage of the cyanobacterial phylum using diversity-
RT   driven genome sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ELR96838.1}.
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DR   EMBL; ALVY01000222; ELR96838.1; -; Genomic_DNA.
DR   RefSeq; WP_006530353.1; NZ_ALVY01000222.1.
DR   STRING; 102232.GLO73106DRAFT_00006370; -.
DR   EnsemblBacteria; ELR96838; ELR96838; GLO73106DRAFT_00006370.
DR   PATRIC; fig|102232.3.peg.3371; -.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; GSP102232:G1HEF-3464-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000011180; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011180};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:ELR96838.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011180};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      356    432       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       8     15       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    202    202       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     102    102       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     187    187       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   432 AA;  46152 MW;  E7CA07195973812B CRC64;
     MVYRIGILGM GTVGTGTVEI LLNPQGRHPL LTEISIKSVG VRSLTKARKV LLPPGTITTN
     LEAIVTDPDI DIVVELLGGL EPSRSLILQA IASGKHVVTA NKAVIARYGD EIYTAANQGN
     VYVLIEGSVG GGIPVIEPLK RSLVANRIES VIGIINGTTN YILTQMSSAG AQFASVLSQA
     QALGYAEADP SADVDGFDAA DKIAILSSLA FNLRVKRAEI FTEGISSIDT VDINYALKLG
     FVIKLLAIAQ LINPDKPNQL QVRVHPTLVP KDHPLASING VYNAILIQGD PIGQVMFYGP
     GAGSGPTASA VVADIMNIVG VLKSNGKTEI LDPLLSCSHQ DYCDLMSIEE LNTRFYVRFL
     TQDLPGVIGE IGTCFGRHHV SLESIVQIGF QDNLAEIVVI THNVKEGNFR QALKEIEAKP
     QIKNIPTVLR VL
//
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