ID L8LKK1_9CHRO Unreviewed; 655 AA.
AC L8LKK1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GLO73106DRAFT_00005070 {ECO:0000313|EMBL:ELR96710.1};
OS Gloeocapsa sp. PCC 73106.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Chroococcaceae; Gloeocapsa.
OX NCBI_TaxID=102232 {ECO:0000313|EMBL:ELR96710.1, ECO:0000313|Proteomes:UP000011180};
RN [1] {ECO:0000313|EMBL:ELR96710.1, ECO:0000313|Proteomes:UP000011180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 73106 {ECO:0000313|EMBL:ELR96710.1,
RC ECO:0000313|Proteomes:UP000011180};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELR96710.1}.
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DR EMBL; ALVY01000223; ELR96710.1; -; Genomic_DNA.
DR RefSeq; WP_006530394.1; NZ_ALVY01000223.1.
DR AlphaFoldDB; L8LKK1; -.
DR STRING; 102232.GLO73106DRAFT_00005070; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2026; Bacteria.
DR OrthoDB; 9787585at2; -.
DR Proteomes; UP000011180; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2310.20; RelE-like; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007712; RelE/ParE_toxin.
DR InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF05016; ParE_toxin; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143011; RelE-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000011180};
KW Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649}.
FT DOMAIN 192..510
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 213..220
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 655 AA; 75305 MW; EBA85B236ED83DF0 CRC64;
MTYTLIVNDT FLNQLLALPR GIGNQVQTKL KHLQEDPISA GGDAKKLKGE NQRLYRVRVS
DYRLIYTFKS KWVNCLAIGH RRDIYRKLHI PDSEVPEEDI DVIRLAEPPG LLNEEVLRNC
FIPEEYWEQL LAIKSEDKLL YLDIPEKIIQ KVLDILYPPS WETLEQKPEK LLTNPDDLTS
FFQGEITPFL LRLDKEQKRI CRYRLGSPVL MKGGPGTGKT IIAVYRVQKL LENGCQSILF
TAHSSALITY SSKLLEQLLG TEPESKGITV NTVGSLIYSY FLGRMGAPSI PSQEKFLHDL
KKAFNDVKGN KLGDFGDFEW KGLIEIIFDR GFSDLLREIQ EVIESCGLRT EAEYLKFNTS
ERINRREKPI IWAVYQRFKE ILKQQGLATQ EHYKFEALKL AQHDEHIQRY DALIIDEAQD
ICPVSLDFIL CMIRNRRKIL LTADSSQSIY KRGFDWSQVH NSLKGSLLSL DNNFRNTKEI
AAACRTILQG EDIYQPCKRK GEIPKIYFSD TEADEDQKIA KFFKDSARNY RIPLTGAAII
CPNIAIAHKY EERMNHTGLK AKYVEGCNIN INSPYIKIIT MDASKGLEFA FVAVVGLKEG
IFPESNSDNL KQLKRLFFVA CSRAMYNLGV FADYSHPSRL INNLEKPYWD RERGN
//
