ID L8LR10_9CHRO Unreviewed; 2358 AA.
AC L8LR10;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:ELR97624.1};
GN ORFNames=GLO73106DRAFT_00014360 {ECO:0000313|EMBL:ELR97624.1};
OS Gloeocapsa sp. PCC 73106.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Chroococcaceae; Gloeocapsa.
OX NCBI_TaxID=102232 {ECO:0000313|EMBL:ELR97624.1, ECO:0000313|Proteomes:UP000011180};
RN [1] {ECO:0000313|EMBL:ELR97624.1, ECO:0000313|Proteomes:UP000011180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 73106 {ECO:0000313|EMBL:ELR97624.1,
RC ECO:0000313|Proteomes:UP000011180};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELR97624.1}.
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DR EMBL; ALVY01000207; ELR97624.1; -; Genomic_DNA.
DR RefSeq; WP_006529541.1; NZ_ALVY01000207.1.
DR STRING; 102232.GLO73106DRAFT_00014360; -.
DR PATRIC; fig|102232.3.peg.2559; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 428071at2; -.
DR Proteomes; UP000011180; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd12115; A_NRPS_Sfm_like; 1.
DR CDD; cd12114; A_NRPS_TlmIV_like; 1.
DR CDD; cd19535; Cyc_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd02142; McbC_SagB-like_oxidoreductase; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR020051; SagB-type_dehydrogenase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR03605; antibiot_sagB; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00881; Nitroreductase; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011180}.
FT DOMAIN 971..1046
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2246..2321
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2358 AA; 267730 MW; 8324F061CA5EAE2B CRC64;
MKDLFQQIAN LTPEQRILFE KRLKQKGLKY SESQSIPKRQ DSDHFSLSFA QQRLWFIQQL
EPDNYSYNVP SAFRLRGELN IQVLERTLNE IVKRHETLRT TFAIDTAKQP VQIITPYESF
SLPMLEVVET DIQSLVEREF QRPFDLTKPL LRLKLLKVSE IEHVLLITTH HIICDRWSVG
VFVREMTILY ASFAQNQASP LPELSIQYAD WAVWQRQRLT DRELDKQINY WKQQLHDLSV
LELPTDRTRR AIPSYQGAQY PIILSRDLSK QLKDLASQEQ VTLFVLLLTA FQILLHRYTH
QNDLVVGTEM ANRDRTETNP LIGLFVNTLV LRMDLSGNPT FRELLKRVRE TTLSAFTHQD
LPFEKLVEIL NPERNLSQMV PLFQVKFDFQ QVLVKPLELS GLSLEHLPFN NDSAKYELRF
NLQDTPTGIN GQIEYSTDLF DEVTIQAMVE HWEILLAGIV QQPEQKISEL PLLSPREQGL
FIEWNQTEKN YPTTDLCIHH LFEAQVKRTP EAIALITEEQ TLTYQELNTK ANQLAHYLKE
LGFKPEAKIG ICLERNCNLI IGLLGILKAG AAYVPLDPAY PQERLDFILE DAQVSALLVD
ELKVINLNQS KSISAESDNL DSQINPSNLA YIIYTSGSTG KPKGVAIEHR NTVQFLHWAK
EVFNPDELKG VLAGTSICFD LSIFEIFVPL SWGGTVILVE NVLALPNVTN QVTLINTVPS
AIYQLLQTNS IPPSVRTINL AGEALQPYLV QQLQHIDKIY NLYGPSEDTT YSTYDLVNPD
SVTIGKAIAN TQVYILDPHH HLVPLGVPGE LYISGSGLAR GYLNRPDLTA EKFIPHFSEG
VRLYKTGDLA KYRRDGKIEY LGRLDHQVKI RGFRVELGEI EAVLALHPGI QETVVTVGED
NQFLIAYVVC KEQVNTSQLR SFLTEKLPSY LIPSIFVQLE KLPRLPNGKI NRKNLPNPND
LRPNLETTYV EPKTELEKAI AQIWQRALNR ETIGIYDNFF ELGGHSLLGM QVIAEVSEAL
GISVPLRSLF QKPTVAGLIE KINNTESAQL EYLPQIIPNK EEHHQPFPLT DIQQAYLIGR
SDAFALGNVA THAYREIETR GISVAQVEQA IAKLITRHDM LRVIITEDSQ QQILSDVPPY
EILTLDLRGQ NPAVTLAEIR ERLSHQILNT QQWPLFEIVA TILDEDRIRF HISFDVLLGD
AWSFQILGAQ LAQLIQNPTL ILPELTLSFR DYVLAELTLE KTELYQASLA YWRNRLPSLP
ASPELPLEKS LAAITNPRFV RRSGQLESQT WQRLKQKASS IGITPSGLIL AAFAEILTMW
SQKPNFTINL TLFNRLPLHP EVNQIIGDFT SSTLFAVDNS IPSSFAIRAK TIQAQLWEDL
DHRYVSGVKV LRELSRLQGG TILMPVVFTS TLTQNISGQS SLSTEVIYSL SQTSQVYLDH
QVLEIEGTLM FNWDTLEELF PVGLLDDMFA AYSNFLERLA NEEEIWETST RLLIPASHLE
KITEINRTEY DFTEKDSLLQ DLFFAQVPVR GNKSAIVTSD FTLTYQELSD RSLTIAHQLQ
ALRVQPNQLV AIVMEKGWEQ IVATLSILAS GAAYVPIDPG LPTERRFLLL QETQVQQILT
QSWLHTSLTW PENLQIICVD KINPHPISEL PSQTTPQDLA YIIYTSGSTG TPKGVMIDHQ
GAVNTILDIN QRFNITAEDK VLALSSLSFD LSVYDIFGTL AAGGTLVIPD ADKTKEPNHW
RELITQYGVT IWNSVPALMQ MLLSQPFSSQ SLRLALLSGD WIPLDLPEQI RTISEDIEII
SLGGATEASI WSILYPVTTV NPHWKSIPYG RPMTNQNFYV LNNNLEPCPM LVTGQLYIGG
KGLASAYWKN PEKTNQSFII HPQNQERLYK TGDLGRYLPD GNIEFLGRED FQVKVSGYRI
ELGEIETTLK QHSALKDAIA LVVDNQRIIA YIIPEQKLEN IEFKLKQPGI RILDNQPKIQ
LNKPDVDETL TQTYLRRQSH RQFLPESIQI NNFSQLLNCL LQLNLPKYPL PKYRYASAGS
LYPVQVYLLI KSEKIEGLAA GYYYYHPLEH QLILLDTYTE INSSLYGNNQ AVFEESAFAL
FLVGELKAIT PMYNDKAKDF CLLEAGYMSQ LLMETAPAQE IGLCPIGTLE FDSLRDKLQL
ESSQILLHSF VGGKIDISWS NQWLKPQKST SINEELTQFL RQKLPEYMIP TVYMLIDALP
LNENGKVDRK LLPKPISIAN QTEFIAPRTD IEKTISAIWQ TSLNVEEIGI YDNFFDLGGN
SFLATQVLAK ICQTFQVDLT VRKFFENPTI ASLALVIEEE NPQKYQEINK VNDDLNLLSE
AEVDLLLEAM LKEETDGE
//
