ID L8M898_9CYAN Unreviewed; 638 AA.
AC L8M898;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=NhaP-type Na+(K+)/H+ antiporter {ECO:0000313|EMBL:ELS04591.1};
GN ORFNames=Xen7305DRAFT_00043260 {ECO:0000313|EMBL:ELS04591.1};
OS Xenococcus sp. PCC 7305.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Pleurocapsales; Xenococcaceae;
OC Xenococcus.
OX NCBI_TaxID=102125 {ECO:0000313|EMBL:ELS04591.1, ECO:0000313|Proteomes:UP000011203};
RN [1] {ECO:0000313|EMBL:ELS04591.1, ECO:0000313|Proteomes:UP000011203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7305 {ECO:0000313|EMBL:ELS04591.1,
RC ECO:0000313|Proteomes:UP000011203};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELS04591.1}.
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DR EMBL; ALVZ01000111; ELS04591.1; -; Genomic_DNA.
DR RefSeq; WP_006508300.1; NZ_ALVZ01000111.1.
DR AlphaFoldDB; L8M898; -.
DR STRING; 102125.Xen7305DRAFT_00043260; -.
DR PATRIC; fig|102125.3.peg.1073; -.
DR eggNOG; COG0025; Bacteria.
DR eggNOG; COG0569; Bacteria.
DR OrthoDB; 570124at2; -.
DR Proteomes; UP000011203; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011203};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 402..496
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 638 AA; 68284 MW; 8403F6131DA9AF6B CRC64;
MEESFELTLQ IVIAVVAGIS AQVIGEYLKV PSIVFLLLLG ILLGSDGIDV LHPNELGVGL
EVIVALAVAV ILFEGGLNLE LRELGKVSGS LRNLVTLGTL ITLVGGGMAA HWLAEFPWAI
AFLYASLVVV TGPTVIGPLL KQVRVDRQVS TILEGEGVLI DPVGAILAVV VLNAILNSDA
APVTVASGLV LRLGIGSLVG VIGGWLLGLF LKNTDRLSEE LKNLVVLAGL WGLFVLSQTL
YSESGLMATV AAGITVKASG LPEERLLKRF KGQLTVLFVS VLFVLLAADL SIASVVALGW
GSVIAVLVLM FVIRPISIVI CTWSSGLNWR QKIFLAWVAP KGIVSASVAS LFAILLTENE
ITGGDAIKAL VFLTIMMTVF CQGLTAGFVA RFLRITLSES TGAVIVGGNN LGRLIAKLFQ
EAGESVVLID TDEEAVKKAQ TDNIPVVQRS GLDAEALEEI GIESMGTFIA LTKNGEINLV
LAQRAMEEFQ PPRVLAVFPK SDSESGNNNT KTNLKVSQAF ISQLSIKTWN TYLQDGQFKL
GTTSLKEKNL SFQQAQIQAL IRSGELLPLL VKREKKLQIV KATEEWRSGD EITCLLHDPR
PKLLKRLSGS NQSSRLALEK LPKMEEISLA SNATDNES
//
