ID L8WPI6_THACA Unreviewed; 437 AA.
AC L8WPI6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN ORFNames=AG1IA_07710 {ECO:0000313|EMBL:ELU38249.1};
OS Thanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus)
OS (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=983506 {ECO:0000313|EMBL:ELU38249.1, ECO:0000313|Proteomes:UP000011668};
RN [1] {ECO:0000313|EMBL:ELU38249.1, ECO:0000313|Proteomes:UP000011668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG-1 IA {ECO:0000313|Proteomes:UP000011668};
RX PubMed=23361014; DOI=10.1038/ncomms2427;
RA Zheng A., Lin R., Xu L., Qin P., Tang C., Ai P., Zhang D., Liu Y., Sun Z.,
RA Feng H., Wang Y., Chen Y., Liang X., Fu R., Li Q., Zhang J., Yu X., Xie Z.,
RA Ding L., Guan P., Tang J., Liang Y., Wang S., Deng Q., Li S., Zhu J.,
RA Wang L., Liu H., Li P.;
RT "The evolution and pathogenic mechanisms of the rice sheath blight
RT pathogen.";
RL Nat. Commun. 4:1424-1424(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362101};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC {ECO:0000256|ARBA:ARBA00010892, ECO:0000256|RuleBase:RU362101}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELU38249.1}.
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DR EMBL; AFRT01002224; ELU38249.1; -; Genomic_DNA.
DR AlphaFoldDB; L8WPI6; -.
DR STRING; 983506.L8WPI6; -.
DR HOGENOM; CLU_036094_1_0_1; -.
DR Proteomes; UP000011668; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR004688; Ni/Co_transpt.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR31611; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR PANTHER; PTHR31611:SF0; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362101};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Reference proteome {ECO:0000313|Proteomes:UP000011668};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362101}.
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 136..163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 205..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 242..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT REGION 290..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 47930 MW; CAC647B81BA93613 CRC64;
MFTKWPRLTI FGRSFLLVAC ELLVNALFWV IAGLLFGRRH ETHGVLNLCL LAWVRIRFAF
GVLSTYIADL GCELDHWLKT WCVIPQFLSC GRPNYPYLQV LMLITSGRAM DCGHCHIDGC
IRSYWRYDHI KKMNNVVLIG LQGAAVSASF LFIVALVNSI ILARILKQRK RRLNGEDVGP
ENSHSLALRI LGPVTKFVNR SWKMYPVGVL FGLGFDTASS IALIAVTALA QRGADGAEMP
RSHIVILPLL FTAGMTLVDS ADSVLMLYSY ADFPEKGFAL FENQETSVSE HSSISSHSST
EAQPGPSTGV GTSTLPPSPK QSITSRPVLP DLERNSSADR RLQEGLGDDE YKITLTEQKT
LDQAAKNTMS GLSIILTLLS ILVAFSISLI TIMGLIGENC DSCREAAEDP NGGGLAGSWW
RGWARVSSVL YANVESS
//
