ID L8WX43_THACA Unreviewed; 825 AA.
AC L8WX43;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Aminopeptidase-P {ECO:0000313|EMBL:ELU40919.1};
GN ORFNames=AG1IA_05051 {ECO:0000313|EMBL:ELU40919.1};
OS Thanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus)
OS (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=983506 {ECO:0000313|EMBL:ELU40919.1, ECO:0000313|Proteomes:UP000011668};
RN [1] {ECO:0000313|EMBL:ELU40919.1, ECO:0000313|Proteomes:UP000011668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG-1 IA {ECO:0000313|Proteomes:UP000011668};
RX PubMed=23361014; DOI=10.1038/ncomms2427;
RA Zheng A., Lin R., Xu L., Qin P., Tang C., Ai P., Zhang D., Liu Y., Sun Z.,
RA Feng H., Wang Y., Chen Y., Liang X., Fu R., Li Q., Zhang J., Yu X., Xie Z.,
RA Ding L., Guan P., Tang J., Liang Y., Wang S., Deng Q., Li S., Zhu J.,
RA Wang L., Liu H., Li P.;
RT "The evolution and pathogenic mechanisms of the rice sheath blight
RT pathogen.";
RL Nat. Commun. 4:1424-1424(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELU40919.1}.
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DR EMBL; AFRT01001262; ELU40919.1; -; Genomic_DNA.
DR AlphaFoldDB; L8WX43; -.
DR STRING; 983506.L8WX43; -.
DR HOGENOM; CLU_011781_2_4_1; -.
DR OMA; LVDQAWG; -.
DR Proteomes; UP000011668; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 3.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ELU40919.1};
KW Hydrolase {ECO:0000313|EMBL:ELU40919.1};
KW Protease {ECO:0000313|EMBL:ELU40919.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011668}.
FT DOMAIN 115..236
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 512..737
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 750..808
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
FT REGION 19..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..328
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 92494 MW; 6937CC697AA5EE09 CRC64;
MSPPPPQIPA ALQNLCGQIP LPGIKRSNTT SSKHTYQSKS SMSSRPTFNT QTSYDSHNSE
KVGFDDPMGY PPKGGLFRAT NIDGVIKLTA VDEEGKAIRT PELDSGYRRT DTTGRLSELR
KLMRNEKIDY YIIPSEDAHQ SEYVAASDRR REYISGFTGS AGTAIVSLNN AYLFTDSRYY
IQAEREIDRN WSLFKVGSGE VKPWNEWILN RARGAAIGID SRLIAHDTAT ALTSALKLRG
MRMAYPQRNL VDQIWKDRPS KSCAPIYIHD MRYAGEHAAS KLDRLRIWLK EYPVPAADLK
YSSPPRPSSP ARDRPTSKPL PDLPPPSRAP SRQSSMRKDS LSRQNSTSSG PHPPTRTPSR
SGISRKNSTS SRENFHRDRG ETAVRLIPHY STFVSNLSCI AWLLNLRGGD VMCNPLFHAY
LWVGVDKATL FVDARKLSDE VKRYLRELKI SVKEVSDVWG YLRKREFGSG KVIIPPKTPY
AVSLMLTYSN YMVAPSWVES NKAIKNKVEI EGFRNAYLRD GVAMTKWFAW LEEQLRAGNT
ITEWEAAEML TQFRKQGEHF MGLAYENISA TGANAGACFH PGSGLIQGPT LPHYSPTKGL
SSAIDVQTPY LNDSGGQYKD GTCDTTRTVH FGHPTDEQCE AFTRVLKGHI AIDSAVFPQG
TTGKQLDVLA RHALWKDGLN YLHGTGHGFG SFLSVHEGPH GFGIDVPLEV GHVITNEPGF
YKEGSFGVRI ESALVVRRVE TKGQFGGDIW LGFERFTCVP IQTRMVKMEL LTKDERRWLK
EHNRKCKDLL APLLEDDARA LRWIRRESTR TSPQQTSAGV TIDWD
//
