ID L8X8P2_THACA Unreviewed; 4134 AA.
AC L8X8P2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily TRA1 {ECO:0000313|EMBL:ELU45462.1};
GN ORFNames=AG1IA_00506 {ECO:0000313|EMBL:ELU45462.1};
OS Thanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus)
OS (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=983506 {ECO:0000313|EMBL:ELU45462.1, ECO:0000313|Proteomes:UP000011668};
RN [1] {ECO:0000313|EMBL:ELU45462.1, ECO:0000313|Proteomes:UP000011668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG-1 IA {ECO:0000313|Proteomes:UP000011668};
RX PubMed=23361014; DOI=10.1038/ncomms2427;
RA Zheng A., Lin R., Xu L., Qin P., Tang C., Ai P., Zhang D., Liu Y., Sun Z.,
RA Feng H., Wang Y., Chen Y., Liang X., Fu R., Li Q., Zhang J., Yu X., Xie Z.,
RA Ding L., Guan P., Tang J., Liang Y., Wang S., Deng Q., Li S., Zhu J.,
RA Wang L., Liu H., Li P.;
RT "The evolution and pathogenic mechanisms of the rice sheath blight
RT pathogen.";
RL Nat. Commun. 4:1424-1424(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELU45462.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFRT01000076; ELU45462.1; -; Genomic_DNA.
DR STRING; 983506.L8X8P2; -.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OMA; CLDLYGQ; -.
DR Proteomes; UP000011668; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 2.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ELU45462.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011668};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000313|EMBL:ELU45462.1};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 2421..2975
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT REPEAT 2817..2850
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 3241..3562
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REPEAT 3658..3690
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 469..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2986..3045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3941..4017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2986..3018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3941..3960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3969..3984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3985..4009
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4134 AA; 465316 MW; E840A0BE249E0708 CRC64;
MSIQQPATAN TTSAGHEVFE GYAAKFTDST QDIKSKLQAA CDIRDSVDQF GQAEAQKFSP
VVLPAMLQVL RETPPAFKKD SSEHQLRNAI LEVFHRLPVS EQMKPIYSDM VSLTTQILRE
DNEENGVLAV KIMLDANRTF KRDMDPHVQG FLDFVRDLYL NMKQTVTELL SEDSPGPPPS
QSNMSINTSV SGREQPEMLR AIASFKVLTE CPIATVYLFQ MHRNTIPSAV KSSIPLAMDF
LQLQAPPQKH AHDEANERNE HWIGVSPAIK HRAHYIDFIT AQVKTLSFVA YVLRGAIESP
VRQYGEIIPP LCVRLLKDCP PESANIRREL MVATRHILST EFRPAFVPLI DCLTSEHILI
GTGVNSQETL RPLAYSMLGD LVHHVRKELS PEQLRRIIYL YSCCLHNPSF SSTIHNMSAK
LLANHVDAIL EKYPKPEAAS TLLALLETCV DKLGAVWAIH QQVANANKEA LGPKADTKTD
TKADPHTKPH ETKDVEMHDI DAMDIDAPRP LTKTLSLVDI ERSKPVQAAA FALENKGEAA
KESKILFRTL LHVFKTVLAG IRTSEGPVPD GELIRRLFQN CVKCLTMYDD GRDGGKEAFE
MLLQVFHEIE PHIFQEVWTT EMQFFIDHVQ DHQNLLAMPQ LLLSSDMVSH QLVAILLRYL
VGKLDTLGDQ SQKSASITLR LFKMCFMSVT VFPELNEPIL FHHLSKLIMD SLRLAAKAAD
PTNYFLLLRG LFRAMGGGKF ESLYNEVLPL LRDMLESLNR QLLAAEPSKQ DLLVELCLTV
PVRLTNLLPF LGFLMRPLVH ALRAGPELVA QGLRTLELCI DNLTQEFLDP TLSPVLRELM
SALHSHLKPQ PGNHQHAHTT VRILGKLGGR NRRLQHQQPQ LEYKGYSPDV TMALKFSGTA
QAVDIGPTCQ LAIRLVQESN AFYRQDAFTF IQRGIDGSEG EGVFSSLVDS LFIALQDSEL
EDKAAAYIRE FSEIVFLNEL SQNVGNKVTK ITSLYMDRVP RLLAATSKHH VERGQVVFGD
MLNDLLAFET KAAPVGRKLR GLECIVHPLG FNLTAACYEE TWPAKLSGCR GIIMLADALG
PKWTSERENS FIRAFLSVLK EMPADPPREV EFIKESILKI LRLCRQAPPF VPPPQPGMDP
ASLPKLPHLV PTLTTELSSP IALVREMAQK SIELLAELTE STPSELLMKC KERLLTPIFA
KPLRALPISL QIGHIDGITY ALNMKPPLPE MNEELLRLLS EALAIADAED RDIVGPGGRG
GPRSNAAVLE QLRVVCIKLL TSSMSVTEFF AKQMATRQKV TSVYFKSLYS PSNEVKKVAH
EGLRTVLNHQ SRLPKDILQT GLRPVLMNLA DAKRLSVPGL EGLARLLELL TNYFKVEIGH
KLLDHFRVIA DPKMLSDAAY QPLADNEEIT KLVRLVNIFH LLPPAANMFL EALVSLVVQV
ETQLHSASPS PFTAALASFL DRFPSESSEY FYRSIGQAPT LRSLRNVISS GLAPNLNAEF
RNNTKLLVDQ CLKDETNNLV LPGLILCTEL SADHPTWLQE HPEVLDALLH LWRSHFLHGS
EDNFVPVEGF ARHVSLLLNL LIGVIEQSPR VDVIFDIVCI YAHRVPLDLS KLRLCLLEHV
TLGASSDLRK QIMQRFVEVF DGDTYNWAHK SQFLRHIVNP LLYAQIKQKE ESESPGNTID
CVDSSIVNGL HSKIWKPMTD QPSDPFPGSD DGLKIEILHM SSLLIQSSSS LMQESRKDVI
KCTWHYIVND DATVKQTAYV TISQFFAVFD SPPKFLTGVW TGLLRPVHTD NRSLTKQAVD
IMVPVLIKAG NSENGPPSWA KSVRRALIDE GHSIPQLLVI HQIIVRHPEF FYPCRELFVP
SMISSLHKLG TVQTATAETR ANALDVLEVI LSWERRAVKE SKESGAGGSS SAWVLPFSMR
ETIISYLVRF ITMTSLEADK LGLPSRALGI LESILKPGGW KDVDVQLQYF HRPLLQVDLN
EANHLPVIVN ATKVFSLIVL SQDDNWLLSH AADLHTLIEK GLRSDEPTLH EYLQPVLQRM
LALVGEPVEG ESSTPGHAIF SFADSMIKDG LQHSQRQLAG TYACLSVLKT MVAVYPAKLE
VYAPHLVKVL QKLVKDHNAA NPTNNPVTSE TTSRLVTLIF EICRDKVSAL GVERRWFLNA
VILVVGHSQT ISLCHYVLGM VREWTLVRPD VTPTLKEKAG MLKHMMGFES RNDTKLLDDY
LNLIYDIYTE PSLKRSDLTT RLESVFLMGC RAKDPAIRCK FVDLFDTSIQ RTVSARLQYA
LGSLSWEFVA EHYWIPLALD LVLGATEDGR TDSLVLRENL AILESSLSRT IYQGTGMDML
QPLRRLLHAD NQVAHELWIS TFRAVWATLP RREQSDAARY VLTLVTKDYH SKQCDLRPNV
IQSILGGVHA CNPPLALPPF VVKYLGKTFN AWHIALEILQ SGLDPHRAEE PHETTYDALA
ELYAELSEDD LFYGLWRRRS IFEETNAALA YEQNGFWSLA QQTYESAQIK ARTGALPFNE
SEYCLWEDHW ILATQKLQQW DPLAELARSE NNADLQLECI WRTTGADREQ IQELLAQVSD
VPTPRRRVFE AYVALTQIPP PNEKNMNFLR IMDESIQLSL RKWVTLPSIM SMAHVPLLQH
FQQFVELQEA AQIFMSLSMT NAQNLEKRSS ELKVVLQAWR ERLPNLWDDI SLWSDLVAWR
THVFEMINKT YVPLIPTTSA SGSSGNSNTY GYRGYHETAW IINRFAHVAR KHQLPDVCHT
SLAKIYTLPN IEISEAFLKL REQARCHYHN PNTSELTSGL EVINNTNLMY FNQSQKAEFY
TLKGMFIAKL GNKDDADRAF QQAVQMDMGL AKAWGEWGKF NDRQFKERPQ EYTLAANAVQ
CYLHAASLHK SAKSRPIIQR IIWLLSVEEP QQPVISPIFE GYKGDIALWY WLTIIPQLLV
ALSYRESKHA RHVLMSISKH YPQALFFHLR TTREEFVQEK KRLTAMQNAR NARQAQNAAA
AKPDGTSGTS TTAGSPPTPK ANGPTPDVTT PAPTPGGGDT APSSDVAQAA NTATMNALDG
AVQRARQPFD HVEDVTSILK TGFPLLTLAL ETMVDQIAMR MKLMPEEDIC RQLSYLHADG
MMAYNRRCNS LTEDNSIPQQ SQMMAANFAR GLQPPNARAA FEQDILMSKL TLRQYVVKVQ
KWRDRYDSQP DHSRTPRKPL QSISHWLAEF HHNKFEEPIE VPGQYIQHKD SPHGFIRIQR
FASRVDFCRS LDMHFRRIGL HGHDGSFHTF AVQTPTARHA RREERGISVL DRRKETRKRN
LNFHLPAAVS LSSTLRLLEN DASYITMQDM LEQHFKEKGI HRDDPQLHFL DKLKTLRNPE
GTKVDFFTLR AELISEISAK LVPANVITNY MTRCMRGPME LWTMRKLFAL QVAASSFMSF
FFSANGRMPQ RFHISRSTGR MFMSDLLPTW NNKHPIIHNA EAVPFRFTPN MQHFVTPIGI
EGLMTSGMMA IARGLTEPEY DLEQQLTLFL RDEVFTWCTT AQNTPPMPDL GFRRAVQHNA
ESLVKKAELM ACRTQADTGA STPQVPIQNI TDLIIRASQE QQLAQMEITY LPWIKHWDLS
SNRCCFSMSV YTKARDMRGT LKHRYTLLGS DRLWESLDEV SVLGYENIQT DTVYGHTGQD
HHRCVNAMSW SSDGELLFSS GDDTRLLVWK HDPRHELAQP LPLDAQDNCL NLRCVNAIKT
GHTNNVFAAK QLAPNSSLVG TCARDSTVRV FDIERAGGTN MPNRGYGRNE AGAEARLHLF
KCHTKEVKRI ATEQSQSTFL TVAGSLQDRT VRQHDLRTPH TCPRCPPPLV KTSHALSALG
SSPLTPWYFV VAGESKHGHL FDRRMVGRDL KDERGDTGVK GQDLVACVAR FGRDAEREAH
DRGAHVTGAR MARSNGDEAS FTYAPWLQST YQVYRYSIYD TPSESTPRQT SIVPNNDSLE
RRDANSARLK SSESSTCGST NDDEESNQNP EEESEGEYDS SDEDDEEMPL QSGSSYGNHA
IILPRSEYRG AANVRTVKDG EWVYASVVNV IEGHPFLPIV AVSGIDDTIK IFEPKAGNKR
KSHIQNSDDI LQQNAESNEH PSLFGRAEMI ATLRMLQATG RIPDLAEGIE CPTQ
//
