ID   L8Y015_TUPCH            Unreviewed;      1064 AA.
AC   L8Y015;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=tRNA (34-2'-O)-methyltransferase regulator WDR6 {ECO:0000256|ARBA:ARBA00040154};
DE   AltName: Full=WD repeat-containing protein 6 {ECO:0000256|ARBA:ARBA00041816};
GN   ORFNames=TREES_T100002393 {ECO:0000313|EMBL:ELV09658.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV09658.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- SIMILARITY: Belongs to the WD repeat WDR6 family.
CC       {ECO:0000256|ARBA:ARBA00038255}.
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DR   EMBL; KB369979; ELV09658.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8Y015; -.
DR   STRING; 246437.L8Y015; -.
DR   eggNOG; KOG0974; Eukaryota.
DR   InParanoid; L8Y015; -.
DR   OrthoDB; 1935601at2759; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR14344; WD REPEAT PROTEIN; 1.
DR   PANTHER; PTHR14344:SF3; WD REPEAT-CONTAINING PROTEIN 6; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          154..187
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   1064 AA;  115281 MW;  BEB75AA6CF736E76 CRC64;
     MMRRMQNLLG HYLIHGFRVR PEPSGDLDSE AMVAVFGSKG LRVVKVSWGQ GHFRELWRSG
     LWNMSDWIWD VRWLEGHVAL ALGHNSVALY DPVVGCLLQE VPCTDRCTLS SACLIGDTWK
     ELTIVAGAVS NQLLVWSPAT ALADDKPVAP DRRVSGHVGV IFSMSYLKSK GLLATASEDR
     SVRIWKVGDL RVPGGRVQNI GHCFGHSARV WQVRLLENYL ISAGEDCVCL VWSHEGEILQ
     AFRGHQGRGI RAIAAHERQA WVITGGDDSG IRLWHLAGRG PPGLGVSGLC FKSRSRPGSL
     KAVTLAGSWR LLAVTDTGAL YLYDLEVKCW EQLLEDKQFR SYCLLEAAPG PEGFGLCAMA
     NGEGHVKVVP INTPAAAVDQ ALFHGKVHSV SWALRGYEEL LLLASGPGGL VACLEISAAP
     SGKAIFVKER CRFLLPPSKQ RWHTCSAFLP PGDFLVFGDR RGSVLLFPSR PDLLKDLAIG
     DKPGTGADGG SGGGEDTSTG WGPVSVLHSL HGKQGVTSVT CQGGYVYTTG RDGAYYQLLV
     RGSQLQPVLR QKSCRGMNWV AGLRMVPDGS TVILGFHANE FVVWSPRSHE KLHVIHCGGG
     HRSWAFSDTE GAMTFAYLKD GDVMLYQALG GCTRPHVILR EGLHGREITC VRRVGSITLG
     PEFGVPSLMH PDSLEPGSEG PGLVDIVITC SEDTTVCVLA LPTATGSAHA LTAVCNHISS
     VRALVVWGVG TPGGSQDPRP GLTARVVSAG GRAEMHCFSI LVTPDPSTPS GLACHVMHLA
     SHRLDEQWDR QRGRHRTVKA DPETRYMCLT VCELDRSGVG PLVAAACSDG AVRLFLLQDS
     GRHLQLFAET FHHKRCVLKV HSFVHEAPQQ QRRLLLCSAA TDGTLAFWDL TTVLDRGSTA
     LEPPVEPGLP YRLGTPCLTL QAHSCGVNSL HTFPTREGHQ LVASGSEDGS LHIFVLAVET
     PELDEAAGHV ELPQLRVLEE FSVPCAHAAH VTGLKILSPS LMVSASIDQR LTFWRLGHGE
     PTFMNSTVYH VADVADMDCW PVSPEFGHRC ALGGQGLEVY NWYD
//