ID L8Y2V5_TUPCH Unreviewed; 511 AA.
AC L8Y2V5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=BOS complex subunit NCLN {ECO:0000256|ARBA:ARBA00034873};
DE AltName: Full=Nicalin {ECO:0000256|ARBA:ARBA00041615};
DE Flags: Fragment;
GN ORFNames=TREES_T100006064 {ECO:0000313|EMBL:ELV09275.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV09275.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; KB370753; ELV09275.1; -; Genomic_DNA.
DR STRING; 246437.L8Y2V5; -.
DR InParanoid; L8Y2V5; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd03882; M28_nicalin_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF0; NICALIN; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 156..243
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELV09275.1"
SQ SEQUENCE 511 AA; 56511 MW; 0D16001E0CC1687A CRC64;
PAGTRNAVLN TEARTMDADV LSRRCVLVRL LDFSYEQYQK ALRQSAGAVV IILPRAMAAV
PQDVVRQFME IEPEMLAMET AVPVYFAVED EALLSIYAQT QAASASQGSA SAAEAQGRAK
GYRVVTAGAW GSRGPLPDES CLQGRLTGLG GEDLPTIVIV AHYDAFGVAP WLALGADSNG
SGVSVLKKME LARLFSRLYT YKRTHAAYNL LFFVSGGGKF NYQGTKRWLE DNLDHTDSSL
LQDNVAXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX SGPQGTDAPR LQVAAHQFPE
VRFSMVHKKI NLAEDVLAWE HERFAIRRLP AFTLSHLESH RAGQRSSIMD VRSRVDSKTL
TRNTRIIAEA LTRVIYNLTE KGTPPDMPVF TEQMPRAAQL LDKDGTFLST LEHYLSRHLK
DVRQHHVKAD KRDPEFVFYD QLKQVMNAYR VKPAVFDLLL AVCIGAYLGM AYVAVQVRQG
GWGRGWPAWP GLTHPAAEGS LSLQDQGPCL L
//
