ID L8Y4C9_TUPCH Unreviewed; 955 AA.
AC L8Y4C9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=R3H domain-containing protein 2 {ECO:0000313|EMBL:ELV09241.1};
GN ORFNames=TREES_T100018365 {ECO:0000313|EMBL:ELV09241.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV09241.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}.
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DR EMBL; KB370794; ELV09241.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y4C9; -.
DR STRING; 246437.L8Y4C9; -.
DR eggNOG; KOG2953; Eukaryota.
DR InParanoid; L8Y4C9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd20882; C1_Stac3; 1.
DR CDD; cd11986; SH3_Stac3_1; 1.
DR CDD; cd11834; SH3_Stac_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR039688; STAC1/2/3.
DR InterPro; IPR035736; Stac3_SH3_1.
DR PANTHER; PTHR15135:SF2; SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR15135; STAC; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF16664; STAC2_u1; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 680..731
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 838..897
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 898..955
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 27..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 104627 MW; C3F0EBDCD165EF80 CRC64;
MLLHRVAAYF GMDHNVDQTG KAVIINKTSN TRMGNREGLS RTSSSRQSST DSELKSLEPR
PWSSTDSDGS VRSMRPPVTK ASSFSGISIL TRGDSIGSSK GGSAGRISRP GMALGAPEVC
NQVTSSQAVR GLLPCTAQQQ QQQQQQQLPA LPPTPQQQPP LNNHMISQHP QQTSFIMAST
GQPLPTSNYS TSSHAPPTQQ VLPPQGYMQP PQQIQVSYYP PGQYPNSNQQ YRPLSHPVAY
SPQRGQQLPQ PSQQPGLQPM MPNQQQAAYQ GMIGVQQPQN QGLLSNQRSS MGGQMQGLVV
QYTPLPSYQV PVGNDSQNVV QPPFQQPMLV PASQSVQGGL PAGGVPVYYS MIPPTQQNGT
STSVGFLQPP GSEQYQMPQS PSPCSPPQMP QQYSGVVVMQ LNVPNGPQPP QNPSMVQWSH
CKYYSMDQRG QKPGDLYNPD SNPQANTQMN SSPVTSPTQS PAPSPVTSLS NVCTGLSPLP
VLTQFPRPGG PAQGDGRYSL LGQPLQYNLS ICPPLLHSQS TYTVHQGQSG LKHGNRSKRQ
ALKSASTDLG TADVVLGRVL EVTDLPEGIT RTEADKLFTQ LAMSGAKIQW LKDAQGLPGG
GGGDNGGTAE NGRLQRLKQL FGKGSTETKE MELLPEPQAN GEAVGAGGGP IYYIYEEEEE
EEEEEEEPPP EPPKLVNDKP HKFKDHFFKK PKFCDVCARM IVLNNKFGLR CKNCKTNIHE
HCQSYVEMQR CFGKIPPGFH RAYSSPLYSD QQYASVKDPS AANRNDPVFE TLRTGVIMAN
KERKKGQADK KNPLAAMMEE EPESARPEEG KPQDGNPTGD KKAEKKTPDD KHKQPGFQQS
HYFVALYRFK ALEKDDLDFP PGEKITVIDD SNEEWWRGKI GEKVGFFPPN FIIRVRAGER
VHRVTRSFVG NREIGQITLK KDQIVVQKGD EAGGYVKVYT GRKVGLFPTD FLEEI
//
