ID L8Y5M4_TUPCH Unreviewed; 633 AA.
AC L8Y5M4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Semaphorin-4C {ECO:0000313|EMBL:ELV11542.1};
GN ORFNames=TREES_T100005878 {ECO:0000313|EMBL:ELV11542.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11542.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; KB365080; ELV11542.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y5M4; -.
DR STRING; 246437.L8Y5M4; -.
DR eggNOG; KOG3611; Eukaryota.
DR InParanoid; L8Y5M4; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11258; Sema_4C; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF16; SEMAPHORIN-4C; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..633
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003998727"
FT DOMAIN 30..497
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 553..633
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 633 AA; 70945 MW; 65958CB6CF0020F8 CRC64;
MAPHWAVWLL AAGLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI QDFLTLTLTE
RTGLLYVGAR EALFAFSMEA LELQGVISWE APTEKKTECI QKGKSNQTEC FNFIRFLQPY
NASHLYVCGT YAFQPKCTYI DMLTFTLERG ELEDGKGKCP YDPAKGHTGL LVDGELYSAT
LNNFLGTEPV ILRNMGPHHA MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKIYFFFS
ERAVEYDCYA EQVVARVARI CKGDVGGART LQRKWTTFLK ARLVCSAPDW QLYFNQLQAV
HTLQGTSWHN TTFFGVFRAR WGDVDLSAIC EYHLEEIQQV FEGPYKEYHE QAQKWGRYTD
PIPTPRPGSC INNWHRRHGY TSSLELPDNT LNFIKKHPLM EEQVGPQWGR PLLVKKDTNF
THLVADRVRG LDGATYTVLF IGTGDGWLLK AVSLGPWVHL IEELQVFDQE PVESLVLSQS
KKLIFAGSRS QLVQLPLADC VKYRSCVDCV LARDPYCAWN VSTSRCVAVG GHSGSLLIQH
VTVSDSLGIC NFPGNKKVRL TPKNITVVVG TDLVLPCRLS SNLARARWTF GGRDLPVEQP
GSFLYDARLQ ALVLMAAQPR HAGASPCFSE VGC
//
