ID L8Y6P8_TUPCH Unreviewed; 1206 AA.
AC L8Y6P8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Anion exchange protein 3 {ECO:0000256|ARBA:ARBA00021515};
DE AltName: Full=Solute carrier family 4 member 3 {ECO:0000256|ARBA:ARBA00032371};
GN ORFNames=TREES_T100005937 {ECO:0000313|EMBL:ELV10660.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV10660.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
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DR EMBL; KB366712; ELV10660.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y6P8; -.
DR STRING; 246437.L8Y6P8; -.
DR eggNOG; KOG1172; Eukaryota.
DR InParanoid; L8Y6P8; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR002979; Anion_exchange_3.
DR InterPro; IPR018241; Anion_exchange_CS.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF15; ANION EXCHANGE PROTEIN 3; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01189; ANIONEXHNGR3.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR PROSITE; PS00219; ANION_EXCHANGER_1; 1.
DR PROSITE; PS00220; ANION_EXCHANGER_2; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 713..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..976
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1082..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1127..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1152..1169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..425
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 444..564
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 926..1135
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..150
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1206 AA; 132909 MW; 626469458A561F75 CRC64;
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDLGKT LAVSRFGDLI SKPPAWDPEK
PSRSYSERDF EFHRHTSHHT HHPLSARLPP PHKLRRLPPT SARHTRRKRK KEKTSAPPSE
GTPPIQEEGA AGVEEEEEEE EEEEGESEVE PVEPLPSVSP PKAKFSIGSD EDDSPGLSGR
ATFAKPLPTA GPRSEGSPQH AVSSPSPRAR ASRVAGEKSR PWSPSASYDL RERLCPGSAL
GNPGGPEQQV PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRT QGGRASPSGL
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV EEETERWGKP
HVASLSFRSL LELRRTIAHG AALLDLEQTT LPGIAHLVVE TMIVSDQIRP EDRASVLRTL
LLKHSPIPVL RPQKPLHMPG GDGHRGKSLK LLEKIPEDAE ATVVLVGCVP FLEQPAAAFV
RLSEAVLLES VLEVPVPVRF LFVMLGPNQT STDYHELGRS IATLMSDKLF HEAAYQADDR
QDLLSAISEF LDGSIVIPPS EVEGRDLLRS VAAFQRELLR KRREREQTKV EMTTRGGYVA
PGKGQQALGP SLPAHLLPFP SPDGCNPSPV LAPPSAWCWL CVPGRFHQEV ASVFQQLLVP
LELSLELGGS EVTPEDDPLL RTGSVFGGLV RDVKRRYPHY PSDLRDALHS QCVAAVLFIY
FAALSPAITF GGLLGEKTEG LMGVSELIVS TAVLGVLFSL LGAQPLLVVG FSGPLLVFEE
AFFKFCRAQD LEYLTGRVWV GLWLVVFVLA LVAAEGSFLV RYISPFTQEI FAFLISLIFI
YETFHKLYKV FTEHPLLPFY PPEGDVEGVP GAGLELNTSA LPPTEGPPGP RNQPNTALLS
LILMLGTFFI AFFLRKFRNS RFLGGKKLTV PTGLSVTSPH KRTWFIPPLG SARPFPPWMM
VAAAVPALLV LILIFMETQI TALIVSQKAR RLLKGSGFHL DLLLIGSLGG LCGLFGLPWL
TAATVRSVTH VNALTVMRTA IAPGDKPQIQ EVREQRVTGV LIASLVGLSI VMGAVLRRIP
LAVLFGIFLY MGVTSLSGIQ LSQRLLLILM PAKHHPEQPY VTKVKTWRMH LFTCIQLACI
ALLWVVKSTA ASLAFPFLLL LTVPLRHCLL PRLFQDRELQ ALDSDDAEPN FDEDGQDEYN
ELHMPV
//
