ID L8Y750_TUPCH Unreviewed; 862 AA.
AC L8Y750;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Abasic site processing protein HMCES {ECO:0000256|ARBA:ARBA00015888};
DE AltName: Full=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein {ECO:0000256|ARBA:ARBA00030390};
DE AltName: Full=Peptidase HMCES {ECO:0000256|ARBA:ARBA00030898};
DE AltName: Full=SRAP domain-containing protein 1 {ECO:0000256|ARBA:ARBA00031130};
GN ORFNames=TREES_T100014497 {ECO:0000313|EMBL:ELV10181.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV10181.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004347}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004347}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004347}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the COPG family.
CC {ECO:0000256|ARBA:ARBA00010720}.
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DR EMBL; KB368299; ELV10181.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y750; -.
DR STRING; 246437.L8Y750; -.
DR eggNOG; KOG2618; Eukaryota.
DR InParanoid; L8Y750; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.90.1680.10; SOS response associated peptidase-like; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR017106; Coatomer_gsu.
DR InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR InterPro; IPR003738; SRAP.
DR InterPro; IPR036590; SRAP-like.
DR PANTHER; PTHR10261; COATOMER SUBUNIT GAMMA; 1.
DR PANTHER; PTHR10261:SF3; COATOMER SUBUNIT GAMMA-1; 1.
DR Pfam; PF01602; Adaptin_N; 2.
DR Pfam; PF08752; COP-gamma_platf; 1.
DR Pfam; PF02586; SRAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF143081; BB1717-like; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 103..222
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 227..339
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 403..540
FT /note="Coatomer gamma subunit appendage Ig-like subdomain"
FT /evidence="ECO:0000259|Pfam:PF08752"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 96206 MW; 30C89E2D5CEFBAC2 CRC64;
MRAVGSAQAQ WAGRRGPPRP EVACGEPPPT TLRAVLGPEL LRRVLRHHYV EEIRQEGRGV
GWRLQPFPAL GEERRSPGGK CPAHTPTIVL TGPGLEGMQK PHYHALGLLY HVRKSDRLAV
SKMVSKFTRH GLKSPFAYCM MIRVASKQLE EEDGSRDSPL FDFIESCLRN KHEMVVYEAA
SAIVNLPGCS AKELAPAVSV LQLFCSSPKA ALRYAAVRTL NKGGFEYKRA IVDCIISIIE
ENSDSKETGL SHLCEFIEDC EFTVLATRIL HLLGQEGPKT NNPSKYIRFI YNRVVLEHEE
VRAGAVSALA KFGAQNEEML PSILVLLRRC VQTELSEPDL LPTPAEVALQ GPSCHSSEVP
LEPLCPGCRC VMDDDNEVRD RATFYLSVLE QRQKALNAGY ILNEQLAAVP EFCGLGPLFK
SSPEPVALTE SETEYVIHCT KHTFTDHMVF QFDCTNTLND QTLENVTVQM EPTEAYEVLC
CVPARSLPYN QPGTCYTLVA LPKDDPTAVA CTFSCMMKFT VKDCDPTTGE TDDEGYEDEY
VQRLPDWRAP GRYRPSYNQG PRSVGPVLLS RLHLDKNADS SERILTPMRW GLVPSWFKES
DPCKLQFNTA NCRSDTMMEK RSFKADGFYE WQRQQGATQR QPYFIYFPQI KTEQGSPPAL
TSGGSSAADS PGHPEKAWDS WRLLTMAGIF DCWAPPEGGD PLYSYTIITV DSCKGLEDIH
HRMPAILDGD EAVSKWLDFG EVPIQEALTL IRPTENITFH PVSPVVNSVR NNTPECLAPV
NLVVSKEFKA SGSSQTMLQW LATKSPKKED PKTLQKDELA VPHRSSELLQ KSPLPKRGSA
GLLERWLKRG QEEPTAKRLH TE
//
