ID   L8Y7N5_TUPCH            Unreviewed;      1303 AA.
AC   L8Y7N5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Nischarin {ECO:0000313|EMBL:ELV10376.1};
GN   ORFNames=TREES_T100010290 {ECO:0000313|EMBL:ELV10376.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV10376.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
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DR   EMBL; KB367803; ELV10376.1; -; Genomic_DNA.
DR   STRING; 246437.L8Y7N5; -.
DR   eggNOG; KOG1259; Eukaryota.
DR   InParanoid; L8Y7N5; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06875; PX_IRAS; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR037904; Nischarin_PX.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR   PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS51450; LRR; 5.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..109
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          447..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          784..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        837..865
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1303 AA;  142534 MW;  CF1ADE9D01CA8619 CRC64;
     MLSGGKLASG GPGQVYVIQV TDGNHEWTVK HRYSDFHDLH EKLVAEKKIN KNLLPPKKII
     GKNSRSLVEK REKDLEVYLQ KLLAAFPGVA PRVLAHFLHF HFYEINGITA ALAEELFEKG
     EQLLGAGEVF AIGPLQLYAV TEQLQQGKPT CASGDAKTDL GHILDFTCRL KYLKVSGTEG
     PFGTSNIQEQ LLPFDLSIFK SLHQVEISHC DAKHIRGLVA SKPTLATMSV RFSATSMKEV
     LVPEASEFDE WEPEGTALEG PVTAVIPTWQ ALTALDLSHN GISVIDESVK LIPKIEFLDL
     SHNGVLVVDN LQHLYNLVHL DLSYNKLSSL EGVHTKLGNI KTLNLAGNLL QSLSGLQKLY
     SLVNLDLSNN RIEQMEEVRS IGSLPCLEHV ALLNNPLSII PDYRTKVLAQ FGERASEVCL
     DNTATTEKEL DTVEVLKAIQ KAKEVKSKLS HPEKKVGEDS RLSAAPCVRP SGSPPSVAPA
     SASLPQPILS NQGIMFVQEE ALASSLSSTD SLTPEDRPVA RGCSDSLESL PVGQAASEDV
     RDVPGAVGGA SPEHTEPEVQ VVPGSGQIIF LPFTCIGYTA TNQDFIQRLS TLIRQAIPSL
     QEFLRQLLTF YKVAGGGQER SQGCFPVYLV YSDKRMVRTA AGDYSGNIEW ASCTLCSAVR
     RSCCAPSEAV KSAAIPYWLL LTPQHLNVIK ADFNPMPNRG THNCRNRNSF KLSRVPLSTV
     LLDPTRSCTQ PRGAFADGHV LELLVGYRFV TAIFVLPHEK FHFLRVYNQL RASLQDLKTV
     VIAKTPASGP GPQGPPADGQ PPEGRARSDQ RAQEAPAEAP LLAPAPAAAS APDLAEAPAP
     APAPAPASAP TEAPAPAPAP QEASAETPAP APAEAPTQYP SETLIQTTSE ENQLPSHLPV
     CPPLRHIASL QGDAVIQLFH SSIAEVENEE LRHLLWSSVV FYQTPGLEAT ACVLLSTRAI
     YLVLHDGLRR YFSEPLQDFW HQKNTDYNNS PFHISQCFVL KLSDLQAVNV GLFDQYFRLT
     GSTPVQVVTC LTRDSYLTHR FLQHLMVVLS SLERTPSPEP VDKDFYSEFG HKATGKMENY
     ELIHSSRVKF TYPSEEEIGD LTFTVAQKVA DPEKAPALSI LLYVQAFQVD TPPPGRCRGP
     LRPKTLLLTS AEIFLLDEDY VHYPLPEFAK GTGHDLMGNV TLDHFGEVSG GLARAGQGQE
     VQWQVFIPSA ESREKLISLL ARQWEALCGR ELPASPAQPS PQPALVACRV QPGLLRTGKQ
     ALVLVKMCSL HRQSSRRTWM CVFGCFQSRL SMSRQPPCRP PLE
//