ID L8Y7V2_TUPCH Unreviewed; 327 AA.
AC L8Y7V2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040};
GN ORFNames=TREES_T100003651 {ECO:0000313|EMBL:ELV10441.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV10441.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU363040}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU363040}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|RuleBase:RU363040}.
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DR EMBL; KB367707; ELV10441.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y7V2; -.
DR STRING; 246437.L8Y7V2; -.
DR eggNOG; KOG4641; Eukaryota.
DR InParanoid; L8Y7V2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|RuleBase:RU363040};
KW Inflammatory response {ECO:0000256|RuleBase:RU363040};
KW Innate immunity {ECO:0000256|RuleBase:RU363040};
KW Membrane {ECO:0000256|RuleBase:RU363040};
KW Receptor {ECO:0000256|RuleBase:RU363040, ECO:0000313|EMBL:ELV10441.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU363040};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT TRANSMEM 116..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT DOMAIN 171..312
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 327 AA; 37825 MW; 25AA925252A98EC0 CRC64;
MQLESLQELN VAFNSLADLP GCSTFSSLSV LTLDHNVVSH PSADFFQSCQ KIRSLKAGNN
PFQCTCELRE FIKNIGQVPR GVVEDWPDSY KCDYPESYKG TPLKDFHPSQ LSCNTVLLIV
TVGATMLLLA VTMTLLCIYL DLPWYLRMMF QWTQTRRRAR NLPLEELQRT LQFHAFISYS
GHDSAWVKNE LVPNLEKEDV RICLHERNFV PGKSIVENIV NCIEKSYKSI FVLSPNFVQS
EWCHYELYFA HHNLFHAGSD NLILILLEPI PQNSIPNKYH KLRALMTQRT YLEWPKEKSK
RGLFWANIRA AFNMKLTLGT ENKDEKT
//
