ID L8Y900_TUPCH Unreviewed; 1099 AA.
AC L8Y900;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Prominin-2 {ECO:0000313|EMBL:ELV11524.1};
DE Flags: Fragment;
GN ORFNames=TREES_T100005893 {ECO:0000313|EMBL:ELV11524.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11524.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR EMBL; KB365080; ELV11524.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y900; -.
DR STRING; 246437.L8Y900; -.
DR eggNOG; KOG0044; Eukaryota.
DR eggNOG; KOG3311; Eukaryota.
DR InParanoid; L8Y900; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF6; PROMININ-2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF05478; Prominin; 2.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 85..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1005..1040
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1053..1088
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELV11524.1"
SQ SEQUENCE 1099 AA; 120801 MW; 436F8D1F6C96A187 CRC64;
TLPSAVAAAD CGSLGPVERL AFAPAARARW LAPRVRAPGP LDSLYGTVRH FLSVVQLNPF
PSDLVKALLN EPASVKVDEV VRYEAGYVVC AVIAGLYLLA VPTTGLCFCC CRCRQRCGGR
VKTEHKALAC ERGALMAFLL LTTLVLLIGM VCAFVTNQRV HEHTGPSVEA VPETLLSLRG
LVSDVPQELQ AVAQQFSRPQ ERVQEELDGV GMSIGSAIHT QLRSTVYLAL ASVSSLGQAL
QVSMDHLRAL NATSVELQVA QRDLEPAVRD HRDRLLALLQ EPGCQGDCAG SLSRARALEL
DADFSQVPTV DDVLHRLKGV PEANFSSMVQ EAERRRQSPA WFLQDNSTFN ALPLLAAMQM
AKEVADLKKM VAQMPKGVKS LAKGFPGSDA TLRWSQALED LERDSRPYLQ EVQRYETYRW
IVGCVLCSTV LLVVVCNLVG LNLGIWGLSA REDPSHSEDK GEAGARFLMV GVGFSFLFAA
PLILLVFATF LVGGNVQTLV CRSWESGELY EGSTGPPSGS LGGLASLLCP ISPCSSQFAD
SPGNLPPSMN LSHLLGLRKN ISVLLAYQQC SRGAALWEVL KLNDSYDLEK HLDISQYTSK
LQQELQNLKV NMQDLDLLSP AAHRDLEALQ SSGIENIRYG DFLVQIQKPV VRTDVGELAQ
ELDRLAQAQG SSALGQQLQE EARGLRSLYQ QKVIPQENLV VSLETREPGA GGEGTVKENK
GPSPGPLLPA HSLTSLCLSL QAELNLHVRA LESSAPDLQE SECFLARGIS YFSQYVDWVR
EEVTQRIATC QPLSGALDNS RVILCDMMAD PWNAFWFCLA WCTFFLVPSI VFAVKTSKYF
RPIRKRLRSG AAQLSVPDVM KASDGSLLGD PGRIPLSKKE GIKWQKPRLT RQALMRCCLV
KWILSSAAPQ GSENTSEQRA ELCTQRGPPN AAPSFTGGWH ALRQFTFRFR GAILACLYSH
RTETVSRGVS RQSQPEVGSG PGASPLTSFP PQDFVVGLSI LLRGTVHEKL KWAFNLYDIN
KDGYITKEEM LAIMKSIYDM MGRHTYPILR EDAPLEHVER FFQKMDRNQD GVVTIDEFLE
TCQKDENIMS SMQLFENVI
//
