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Database: UniProt
Entry: L8Y9M1_TUPCH
LinkDB: L8Y9M1_TUPCH
Original site: L8Y9M1_TUPCH 
ID   L8Y9M1_TUPCH            Unreviewed;       553 AA.
AC   L8Y9M1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein {ECO:0000256|ARBA:ARBA00019443};
GN   ORFNames=TREES_T100016471 {ECO:0000313|EMBL:ELV11670.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11670.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC       triphosphate receptor (ITPR) Ca(2+) release.
CC       {ECO:0000256|ARBA:ARBA00003856}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus outer membrane
CC       {ECO:0000256|ARBA:ARBA00004494}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004494}.
CC   -!- SIMILARITY: Belongs to the ITPRIP family.
CC       {ECO:0000256|ARBA:ARBA00005554}.
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DR   EMBL; KB365060; ELV11670.1; -; Genomic_DNA.
DR   RefSeq; XP_006166479.1; XM_006166417.2.
DR   RefSeq; XP_006166480.1; XM_006166418.2.
DR   RefSeq; XP_006166481.1; XM_006166419.2.
DR   RefSeq; XP_006166482.1; XM_006166420.2.
DR   RefSeq; XP_006166483.1; XM_006166421.2.
DR   RefSeq; XP_014438841.1; XM_014583355.1.
DR   RefSeq; XP_014438842.1; XM_014583356.1.
DR   AlphaFoldDB; L8Y9M1; -.
DR   STRING; 246437.L8Y9M1; -.
DR   GeneID; 102486307; -.
DR   KEGG; tup:102486307; -.
DR   CTD; 85450; -.
DR   eggNOG; ENOG502QRDF; Eukaryota.
DR   InParanoid; L8Y9M1; -.
DR   OrthoDB; 5299698at2759; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.1410.40; -; 1.
DR   InterPro; IPR026250; ITPRIP-like.
DR   InterPro; IPR024810; Mab-21-like.
DR   InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR   PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR   PANTHER; PTHR10656:SF8; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN; 1.
DR   Pfam; PF20266; Mab-21_C; 1.
DR   PRINTS; PR02107; INOS145TPRIP.
DR   SMART; SM01265; Mab-21; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000313|EMBL:ELV11670.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..553
FT                   /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012723147"
FT   DOMAIN          426..482
FT                   /note="Mab-21-like HhH/H2TH-like"
FT                   /evidence="ECO:0000259|Pfam:PF20266"
FT   REGION          109..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          38..79
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   553 AA;  62839 MW;  F5443C31F1769E7C CRC64;
     MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEDEIIRK MQAHQEKLQL EQLRLEEEVA
     RLVAEKEALE QVAEEGQQQN DTRAAWDLWS TLCMIIFLMI EVWRQDHQDG PSPECLGGDE
     DELPGPGSAP LRGLTLPNKA TLSHFYERCI RGATADAART REFVEGFVDD LLEALRSLCN
     RDTDMEVEDF IGVDSMYENW QVDRPLLCDL FVPFTPPEPY RFHPELWCSS RSVPLDRQGF
     GQIKVVRADG DALGCICGKT KLGEDMLCLL HGKNSVAQPC GGEMEDLLCA RGSPYLDTVQ
     VMKWFQVALT RAWHRIARKY EFDLAFGQLD TPGSLKIKFR SGKFMPFNLI PVIQCDDTDL
     YFVSHLPREP PGDTQAPSTD WLLSFAVYER HFLRMTSKAL PEGSCHLSCL QIASFLLSKQ
     SRLTGPSGLS NYHLKTALLH LLLSRRACDW QAEQLDRRLH ELLYFLEKSL LEKKLHHFFI
     GNCKVPEAMG LPEAVRRAEP LNLFRPFVLQ RSLYRKTVDS FYEMLKNAPA LISEYSLHVP
     ADHGSLPPKA VAL
//
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