ID L8Y9M1_TUPCH Unreviewed; 553 AA.
AC L8Y9M1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein {ECO:0000256|ARBA:ARBA00019443};
GN ORFNames=TREES_T100016471 {ECO:0000313|EMBL:ELV11670.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11670.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC triphosphate receptor (ITPR) Ca(2+) release.
CC {ECO:0000256|ARBA:ARBA00003856}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004494}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004494}.
CC -!- SIMILARITY: Belongs to the ITPRIP family.
CC {ECO:0000256|ARBA:ARBA00005554}.
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DR EMBL; KB365060; ELV11670.1; -; Genomic_DNA.
DR RefSeq; XP_006166479.1; XM_006166417.2.
DR RefSeq; XP_006166480.1; XM_006166418.2.
DR RefSeq; XP_006166481.1; XM_006166419.2.
DR RefSeq; XP_006166482.1; XM_006166420.2.
DR RefSeq; XP_006166483.1; XM_006166421.2.
DR RefSeq; XP_014438841.1; XM_014583355.1.
DR RefSeq; XP_014438842.1; XM_014583356.1.
DR AlphaFoldDB; L8Y9M1; -.
DR STRING; 246437.L8Y9M1; -.
DR GeneID; 102486307; -.
DR KEGG; tup:102486307; -.
DR CTD; 85450; -.
DR eggNOG; ENOG502QRDF; Eukaryota.
DR InParanoid; L8Y9M1; -.
DR OrthoDB; 5299698at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.1410.40; -; 1.
DR InterPro; IPR026250; ITPRIP-like.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF8; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:ELV11670.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..553
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012723147"
FT DOMAIN 426..482
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
FT REGION 109..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 38..79
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 553 AA; 62839 MW; F5443C31F1769E7C CRC64;
MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEDEIIRK MQAHQEKLQL EQLRLEEEVA
RLVAEKEALE QVAEEGQQQN DTRAAWDLWS TLCMIIFLMI EVWRQDHQDG PSPECLGGDE
DELPGPGSAP LRGLTLPNKA TLSHFYERCI RGATADAART REFVEGFVDD LLEALRSLCN
RDTDMEVEDF IGVDSMYENW QVDRPLLCDL FVPFTPPEPY RFHPELWCSS RSVPLDRQGF
GQIKVVRADG DALGCICGKT KLGEDMLCLL HGKNSVAQPC GGEMEDLLCA RGSPYLDTVQ
VMKWFQVALT RAWHRIARKY EFDLAFGQLD TPGSLKIKFR SGKFMPFNLI PVIQCDDTDL
YFVSHLPREP PGDTQAPSTD WLLSFAVYER HFLRMTSKAL PEGSCHLSCL QIASFLLSKQ
SRLTGPSGLS NYHLKTALLH LLLSRRACDW QAEQLDRRLH ELLYFLEKSL LEKKLHHFFI
GNCKVPEAMG LPEAVRRAEP LNLFRPFVLQ RSLYRKTVDS FYEMLKNAPA LISEYSLHVP
ADHGSLPPKA VAL
//