ID L8YAH9_TUPCH Unreviewed; 214 AA.
AC L8YAH9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=F-box only protein {ECO:0000256|RuleBase:RU369085};
GN ORFNames=TREES_T100002239 {ECO:0000313|EMBL:ELV11970.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11970.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC protein) E3 ubiquitin-protein ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins and plays a role in several biological processes such as cell
CC cycle, cell proliferation, or maintenance of chromosome stability.
CC Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated
CC by CK2 following growth factor deprivation, leading to their
CC degradation. In contrast, does not mediate ubiquitination of TTI1 and
CC TELO2 when they are part of the mTORC2 complex. As a consequence,
CC mTORC1 is inactivated to restrain cell growth and protein translation,
CC while mTORC2 is the activated due to the relief of feedback inhibition
CC by mTORC1. Plays a role in maintaining epithelial cell survival by
CC regulating the turn-over of chromatin modulator PRMT4 through
CC ubiquitination and degradation by the proteasomal pathway. Regulates
CC also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination
CC and thereby plays a role in adipocyte differentiation.
CC {ECO:0000256|RuleBase:RU369085}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|RuleBase:RU369085}.
CC -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts
CC with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
CC {ECO:0000256|RuleBase:RU369085}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369085}.
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DR EMBL; KB364809; ELV11970.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YAH9; -.
DR STRING; 246437.L8YAH9; -.
DR eggNOG; KOG2997; Eukaryota.
DR InParanoid; L8YAH9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd22089; F-box_FBXO9; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR045118; FBXO9/FBXO48.
DR PANTHER; PTHR12874; F-BOX ONLY PROTEIN 48-RELATED; 1.
DR PANTHER; PTHR12874:SF9; F-BOX ONLY PROTEIN 9; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU369085};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU369085}.
FT DOMAIN 107..147
FT /note="F-box"
FT /evidence="ECO:0000259|Pfam:PF12937"
SQ SEQUENCE 214 AA; 24709 MW; 351138C9DAE677BF CRC64;
MAQLQMFRAQ WMFELAPGVS SSNLESRHCR TAKGSLLKAA ADTKGKQELA KEEKPFAYLL
RFLFSIEDDD DESKTADLLS CFQQELTFQE SVRKLCQPEL ESSQTHISVL PMEVLMYIFR
WVVSSDLDLR SLEQLSLVCR GFYICARYIR FFPDGHVMML TTPEEPQSIV PRLRTRNTRS
TGETAVSAFE IDKMYTPLFF ARVRSYTAFS ERPL
//
