ID L8YAI4_TUPCH Unreviewed; 1760 AA.
AC L8YAI4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Kinesin-like protein KIF13A {ECO:0000313|EMBL:ELV12074.1};
DE Flags: Fragment;
GN ORFNames=TREES_T100012594 {ECO:0000313|EMBL:ELV12074.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12074.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; KB364734; ELV12074.1; -; Genomic_DNA.
DR STRING; 246437.L8YAI4; -.
DR eggNOG; KOG0241; Eukaryota.
DR InParanoid; L8YAI4; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22729; FHA_KIF13A; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF5; -; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 2.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 1..358
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 13..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1570..1669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..415
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 613..640
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1090..1117
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 108..115
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELV12074.1"
SQ SEQUENCE 1760 AA; 195121 MW; 8AF04EF96379DD56 CRC64;
ELELNTKCVV EMEGNQTVLH PPPSNSKQGE SPSDEDSGCA PPASGSRLLC PALKRARLTQ
PHAVTGGAPV WVSHSGRAAG QEVVFKCLGE GILEKAFQGY NACIFAYGQT GSGKSFSMMG
HAEQLGLIPR LCCALFRRIS LEQNESQTFK VEVSYMEIYN EKVRDLLDPK GSRQSLKVRE
HKVLGPYVDG LSQLAVTSFE DIESLMSEGN KSRTVAATNM NEESSRSHAV FNIIITQTLY
DLQSGNSGEK VSKVSLVDLA GSERVSKTGA AGERLKEGSN INKSLTTLGL VISSLADQAA
GKGKNKFVPY RDSVLTWLLK DNLGGNSQTS MIATISPAAD NYEETLSTLR YADRAKRIVN
HAVVNEDPNA KVIRELREEV EKLREQLSRA EAMKAPELKE KLEESEKLIK ELTVTWEEKL
RKTEEIAQER QRQLESMGIS LETSGIKVGE DKCYLVNLNA DPALNELLVY YLKDHTRVGA
DTSQDIQLFG IGIQPEHCEI AIASDGDVTL TPKENARSCV NGAQVCSGTQ LWHGDRILWG
NNHFFRINLP KRKRRDWLKD LEKETGPPEH DLDAASEASS EPDYNYEFAQ MEVIMKTLNS
NDPVQNVVQV LEKQYLEEKR SALEEQRLMY ERELEQLRQQ LSPERQAPAP PPAGPTAARR
HSSKDELFRQ SLAKLREQLV KANTLVREAN FLAEEMRKLT DYQVTLQIPA TNLSANRKRG
VIVSEPAIQV RRKGKSTQVW TIEKLENKLI DMRDLYQEWK EKVPEAKRLY GKRGDPFYEA
QENHNLIGVA NVFLECLFCD VKLQYAVPII SQQGEVAGRL HVEVMRVTGA VPERVVEDDS
SENSSESGSL EVVDSSGEIA HRVKKLTCRV KIKEATGLPL NLSNFVFCQY TFWDQCESTV
AAPVVDPDVP SPQSKDARYS VTFSHCKDYV VNVTEEFLEF ISEGALAIEV WGHRCAGNGS
SIWEVDSLHA KTRTLHDRWN EVTRRIEMWI SILELNELGE YAAVELHQAK DVNTGGIFQL
RQGHSRRVQV TVKPVQHSGT LPLMVEAILS VSIGCVTARS TKLQRGLDSY QEEDLNCVRE
RWSDALIKRR EYLDEQIKKV SNKKEKTEDD VEREARLVGQ WVGLTEERNA VLVPAPGSGI
PGAPADWVPP PGMETHIPVL FLDLNADDLS ANEQLVGPHA SGVNSILPKE HGSQFFYLPI
IKHSDEEVSA TASWDSSVHD SVHLNRVTPQ NERIYLIVKA TVQLSHPAAM ELVLRKRIAA
NIYNKQATEE IEDRETLALL AARSDSEGTC DGETYIEKYT RGVLQLENIL SLERLRPGSH
PAVTVKEALS AKARHIRRSV STPNVHNVSS SRGDLSGFDE DDKGWLENQL DVSDYSSSYQ
DVACYGTLPR DSPRRSKEGS GCAAESPHAL TVSPFKAFSP QPPKFFKPLM PVKEEHKKRT
ALEARPLLSQ ESVLPPQAPS PGCIVPPGSN GSCMPLEHDS KREKKIDSEE EEGELEALNR
TLMSSQPYVP VEFADFSVYN AGLESREWFS KADLSSSRAL EKEVSRSPTA SSITSGYFSH
SASNATLSDV AVPTSDSSDQ LAVQTRDADS SEHGGPSLGP EFRPSPHREL TEGERGSGQE
KVTAGPQQED SALPGASLAW QSPPEKSADV PGRTGPRLGL SSRPARELCP REVTVEHTTD
VLEDHAFTEF MGVADGKDLD GVRDSAGALL SRRDRPNKAE STRVPDGPQP PGRPCSELEN
DQVIRVPEAA LRFRAVREHV
//
