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Database: UniProt
Entry: L8YAN0_TUPCH
LinkDB: L8YAN0_TUPCH
Original site: L8YAN0_TUPCH 
ID   L8YAN0_TUPCH            Unreviewed;       402 AA.
AC   L8YAN0;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Corticosteroid-binding globulin {ECO:0000256|ARBA:ARBA00039186};
DE   AltName: Full=Serpin A6 {ECO:0000256|ARBA:ARBA00043180};
DE   AltName: Full=Transcortin {ECO:0000256|ARBA:ARBA00041777};
GN   ORFNames=TREES_T100005841 {ECO:0000313|EMBL:ELV12139.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12139.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- FUNCTION: Major transport protein for glucocorticoids and progestins in
CC       the blood of almost all vertebrate species.
CC       {ECO:0000256|ARBA:ARBA00037222}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   EMBL; KB364711; ELV12139.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8YAN0; -.
DR   STRING; 246437.L8YAN0; -.
DR   MEROPS; I04.954; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; L8YAN0; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd19554; serpinA6_CBG; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF34; CORTICOSTEROID-BINDING GLOBULIN; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Steroid-binding {ECO:0000256|ARBA:ARBA00022665};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..402
FT                   /note="Corticosteroid-binding globulin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003998404"
FT   DOMAIN          47..401
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
SQ   SEQUENCE   402 AA;  45144 MW;  F088CE31C4270B33 CRC64;
     MTLVWYTCLF WLSTSCLWTI QAQDSAANVN IRSPHRGLAP TNVDFAFSLF KHLVSLAPDR
     NVFISPVSIS IALAMLSLGT YGPTRTQLLQ GLGFNITEIS ETEIHQRFQH LLNLLRESET
     SLEMTLGTTL FYDRSLEPLE SFSADIKKYY ESEVLAADFQ DGAKASRQIK EYIKNKTQGE
     IEDLFSDVES PGVILVNYIF FKGMWAQPFD PVSRVQNFYV NETLTVEVPM LFQSSTIMHL
     YDPELACRVV KLDYEGNGTA FFILPDRGRV DTVISTLTRD TIQRWSQTLT SGQVNLYIPK
     FSISGAHDLT DVLTGMGIAG LFANWSDFSG ITQEAPVKLS KVVHKATLQL DERGMKAAAH
     TEVSPEQSSE PHTILFNQPF VILVFDDFSW SSLFMGKVEN PA
//
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