ID L8YB44_TUPCH Unreviewed; 618 AA.
AC L8YB44;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN ORFNames=TREES_T100018171 {ECO:0000313|EMBL:ELV12185.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12185.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
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DR EMBL; KB364676; ELV12185.1; -; Genomic_DNA.
DR RefSeq; XP_006165360.1; XM_006165298.2.
DR RefSeq; XP_014438350.1; XM_014582864.1.
DR AlphaFoldDB; L8YB44; -.
DR STRING; 246437.L8YB44; -.
DR GeneID; 102502937; -.
DR KEGG; tup:102502937; -.
DR CTD; 26035; -.
DR eggNOG; KOG3760; Eukaryota.
DR InParanoid; L8YB44; -.
DR OrthoDB; 5392022at2759; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR Pfam; PF21174; Glce_b_sandwich; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 417..608
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
FT REGION 67..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 69621 MW; 68DF6E75AD1FCE0A CRC64;
MRCLAARVSY KTLIIICALF TLVTVLLWNK CSSDKAIQFP RHSSSGFRVD GLDKRAAASE
SNSYANHVAR QQAEEGGPQE QQKAPPVVGG FNGNGGSKVL GLKYEEIDCL INDEHTVKGR
REGSEVFLPF TWVEKYFDVY GKVVQYDGYE RFEFSHSYSK VYAQRAPYHP DGVFMSFEGY
NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHVEVYETAE
DRDKGSKPGD WSVPKGCFMA SVADKSRLTN VKQFIAPETS EGVSLQLGNT KDFIISFDLK
FLTNGSVSVV LETTEKNQLF TVHYVSNTQL IAFKERDIYY GIGPRTSWST VTRDLVTDLR
KGVGLSNTKA VKPTKIMPRK VVRLIAKGKG LLDNITISTT AHMAAFFAAS DWLVRNQDEK
GGWPIMVTRK LGEGFKSLEP GWYSAMAQGQ AISTLVRAYL LTKDHVFLSS ALRATAPYKF
LSEQHGVKAV FMNKHDWYEE YPTTPSSFVL NGFMYSLIGL YDLKETAGEK LGKEARLLYE
RGMESLKAML PLYDTGSGTI YDLRHFMLGI APNLARWDYH TTHINQLQLL STIDESPIFK
EFVKRWKSYL KGSRAKHN
//
