GenomeNet

Database: UniProt
Entry: L8YE81_TUPCH
LinkDB: L8YE81_TUPCH
Original site: L8YE81_TUPCH 
ID   L8YE81_TUPCH            Unreviewed;       426 AA.
AC   L8YE81;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma {ECO:0000313|EMBL:ELV12691.1};
GN   ORFNames=TREES_T100005799 {ECO:0000313|EMBL:ELV12691.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12691.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB364392; ELV12691.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8YE81; -.
DR   STRING; 246437.L8YE81; -.
DR   eggNOG; KOG4637; Eukaryota.
DR   InParanoid; L8YE81; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 2.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ELV12691.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}; Transferase {ECO:0000313|EMBL:ELV12691.1}.
FT   DOMAIN          31..125
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          323..417
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   COILED          146..173
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          211..259
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   426 AA;  50319 MW;  F3E69EA8BCE1F828 CRC64;
     MPMFWVTVMM QFSRRTMTAA GSSSKLALDS WMSGRVWEEV NDKLRDMPDG TFLVRDASTK
     MQGDYTLTLR KGGNNKLIKI YHRDGKYGFS DPLTFTSVVE LINHYHHESL AQYNPKLDVK
     LMYPVSRYQQ DQLVKEDNID AVGKKLQEYH SQYQEKSKEY DRLYEEYTRT SQEIQMKRTA
     IEAFNETIKI FEEQCHTQEQ HSKEYIERFR REGNEKEIER IMMNYDKLKS RLGEIHDSKM
     RLEQDLKKQA LDNREIDKKM NSIKPDLIQL RKIRDQHLVW LNHKGVRQKR LNAWLGIKNE
     DADETYFINE EDENLPHYDE KTWFVEDINR VQAEDLLYGK PDGAFLIRES SKKGCYACSV
     VADGEVKHCV IYNTARGYGF AEPYNLYSSL KELVLHYQQT SLVQHNDSLN VRLAYPVHAQ
     MPSLCR
//
DBGET integrated database retrieval system