ID L8YE81_TUPCH Unreviewed; 426 AA.
AC L8YE81;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma {ECO:0000313|EMBL:ELV12691.1};
GN ORFNames=TREES_T100005799 {ECO:0000313|EMBL:ELV12691.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12691.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; KB364392; ELV12691.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YE81; -.
DR STRING; 246437.L8YE81; -.
DR eggNOG; KOG4637; Eukaryota.
DR InParanoid; L8YE81; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ELV12691.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transferase {ECO:0000313|EMBL:ELV12691.1}.
FT DOMAIN 31..125
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 323..417
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 146..173
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 211..259
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 426 AA; 50319 MW; F3E69EA8BCE1F828 CRC64;
MPMFWVTVMM QFSRRTMTAA GSSSKLALDS WMSGRVWEEV NDKLRDMPDG TFLVRDASTK
MQGDYTLTLR KGGNNKLIKI YHRDGKYGFS DPLTFTSVVE LINHYHHESL AQYNPKLDVK
LMYPVSRYQQ DQLVKEDNID AVGKKLQEYH SQYQEKSKEY DRLYEEYTRT SQEIQMKRTA
IEAFNETIKI FEEQCHTQEQ HSKEYIERFR REGNEKEIER IMMNYDKLKS RLGEIHDSKM
RLEQDLKKQA LDNREIDKKM NSIKPDLIQL RKIRDQHLVW LNHKGVRQKR LNAWLGIKNE
DADETYFINE EDENLPHYDE KTWFVEDINR VQAEDLLYGK PDGAFLIRES SKKGCYACSV
VADGEVKHCV IYNTARGYGF AEPYNLYSSL KELVLHYQQT SLVQHNDSLN VRLAYPVHAQ
MPSLCR
//