ID L8YEH2_TUPCH Unreviewed; 436 AA.
AC L8YEH2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=von Willebrand factor A domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029542};
GN ORFNames=TREES_T100002209 {ECO:0000313|EMBL:ELV12796.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12796.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR EMBL; KB364377; ELV12796.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YEH2; -.
DR STRING; 246437.L8YEH2; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG3544; Eukaryota.
DR InParanoid; L8YEH2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF77; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 56..235
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 236..327
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 330..418
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 407..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 46257 MW; 5F7C9DBEE9AF7C22 CRC64;
MRGRGFLRGR GPAVARAAAH PGAQAWTALG LALSLRLALT RSSSEGGPSA SVPQGDLLLL
LDSSASVSHY EFSRVREFLG QLVTPLPLGP GALRVSLVHV GSQPYTEFPF GHHSSGGAVQ
DAIRVAAQRM GDTNTGLALA YAKEQLFAEA AGARPGVPKV LMWVTDGGSS DPVGPPMQEL
KDLGVTVFIV STGRGNLLEL SAAASAPAEK HLHFVDVDDL HIIAQELRRS VLDAMQPQQL
RASEVMSDGF HLAWPPLLTA ESGYYVLELV PSAEPRAVRR QQLPGNTTSW TWTGLDPDSD
YDVTLVPESN VHFVRPQHLR VHTLPADEAG PERIVISHVR PRSLRVSWSP ALGPAAALGY
HLGPLQGGAV HRVEVPAGRN STTLQGLAPA TDYLVTVTAV LRSGREKALS AKACTPDGER
SRAPRPRPPD AGGRGP
//
