ID L8YF54_TUPCH Unreviewed; 1277 AA.
AC L8YF54;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=TREES_T100013631 {ECO:0000313|EMBL:ELV13759.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13759.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; KB360584; ELV13759.1; -; Genomic_DNA.
DR STRING; 246437.L8YF54; -.
DR eggNOG; ENOG502QR6U; Eukaryota.
DR InParanoid; L8YF54; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR CDD; cd11729; ADDz_Dnmt3a; 1.
DR CDD; cd20154; PWWP_DNMT3A; 1.
DR Gene3D; 2.20.70.90; -; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.720.50; PWWP, helical domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025766; ADD.
DR InterPro; IPR044108; ADD_DNMT3A.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR040552; DNMT3_ADD_GATA1-like.
DR InterPro; IPR049554; DNMT3_ADD_PHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR23068:SF10; DNA (CYTOSINE-5)-METHYLTRANSFERASE 3A; 1.
DR PANTHER; PTHR23068; DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED; 1.
DR Pfam; PF17980; ADD_DNMT3; 1.
DR Pfam; PF21255; ADDz_Dnmt3b; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF00855; PWWP; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00293; PWWP; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51533; ADD; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1..44
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 657..715
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 847..979
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51533"
FT REGION 241..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 153..233
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 266..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1075
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1277 AA; 142771 MW; 61F19DBC7D5E0C4B CRC64;
MMGFRYRCQQ CHNYQLCQNC FWRGHASGPH SNQHQMKEHS SWKSPAKKLS HAISKSLGCV
PTREPPHPVF PEQPEKPLDL AHIVLLYSKD APSHLADEHA LIASYVARLQ HCARVLESPS
RLDEEHRLIA RYAARLAAEA GNVTRPPTDL SFNFDANKQQ RQLIAELENK NREILQEIQR
LRLEHEQASQ PTPEKAQQNP TLLAELRLLR QRKDELEQRM SALQESRREL MVQLEGLMKL
LKAQATGSPH TSPTHGGGRP MPMPVRSTSA GSTPTHCPQD SLSGVGGDVQ EAFAQGTRRN
LRNDLLVAAD SITNTMSSLV KELHSAEEGA EEDEEKMQNG KDRGKGSTTG PRVGLAPQEE
PDKEDTREGE EQEEPRGKEE RQEASTTARK VGRPGRKRKH PPVESSDTPK DPAVTSKSPS
MAQDSGPSEL LPNGDLEKRS EPQPEEGSPA GGQKGGPPAE GEGAAETPPE ASRAVENGCC
TPKGGRGAPA EEGKEQKETN IESVKMEASG SRGRLRGGLG WESSLRQRPM PRLTFQAGDP
YYISKRKRDE WLARWKREAE KKAKVIAVMN AVEESQGSVE AQKVEDASPP AVQPXXXXXE
ARKGEDATPP AVQQPTDPAS PTVATTPEPV GADAGDKNAT KAADDEPEYE DGRGFGIGEL
VWGKLRGFSW WPGRIVSWWM TGRSRAAEGT RWVMWFGDGK FSVVCVEKLM PLSSFCSAFH
QATYNKQPMY RKAIYEVLQV ASSRAGKLFP TCHDSDESDT AKAVEVQNKQ MIEWALGGFQ
PSGPKGLEPP EEEKNPYKEV YTDMWVEPEA AAYAPPPPAK KPRKSTTEKP KVKEIIDERT
RERLVYEVRQ KCRNIEDICI SCGSLNVTLE HPLFIGGMCQ NCKNCFLECA YQYDDDGYQS
YCTICCGGRE VLMCGNNNCC RCFCVECVDL LVGPGAAQAA IKEDPWNCYM CGHKGTYGLL
RRRDDWPSRL QMFFANNHDQ EFDPPKVYPP VPAEKRKPIR VLSLFDGIAT GLLVLKDLGI
QVDRYIASEV CEDSITVGMV RHQGKIMYVG DVRSVTQKHI QEWGPFDLVI GGSPCNDLSI
VNPARKGLYE GTGRLFFEFY RLLHDARPKE GDDRPFFWLF ENVVAMGVSD KRDISRFLES
NPVMIDAKEV SAAHRARYFW GNLPGMNRPL ASTVNDKLEL QECLEHGRIA KFSKVRTITT
RSNSIKQGKD QHFPVFMNEK EDILWCTEME RVFGFPVHYT DVSNMSRLAR QRLLGRSWSV
PVIRHLFAPL KEYFACV
//
