ID L8YFJ9_TUPCH Unreviewed; 962 AA.
AC L8YFJ9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 3 {ECO:0000256|ARBA:ARBA00040040};
GN ORFNames=TREES_T100019900 {ECO:0000313|EMBL:ELV13800.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13800.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|ARBA:ARBA00004267}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004394}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; KB360345; ELV13800.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YFJ9; -.
DR STRING; 246437.L8YFJ9; -.
DR eggNOG; ENOG502SBIG; Eukaryota.
DR InParanoid; L8YFJ9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF19; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 5.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..91
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 178..494
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 643..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 109316 MW; AD3E134977129ED8 CRC64;
MGSVRCKLAH YLEDLEEADF KKFKMHLEDY PPLKGCIPLP RGQTEKADHV DLATLMIDFN
GEEKAWAMAV GIFAAINRRD LHEKAKWDEP DWNYCRKYRR HVRSKFQCIE DRNARLGESV
NLNKRYTRLR LVKEHPNRQE REHELLAIGR TKTWDRPVTS VKLEFLFDPD DEHVEPVHTV
VFQGAAGIGK TILARKIMLD WSSGRLYQDR FDYLFYIHCR EVSLVTRRSL GDLIASCCPD
SNPPLGKIVS KPSRILFLMD GFDELQGAFD EHEGALCTDW QRAERGDVLL SSLIRKKLLP
EASLLITTRP VALEKLHHLL DHPRHVEIVG FSEARRKEYF FKYFSDESQA REAFSLIQEN
EVLFTMCFIP LVCWIVCTGL RQQMESGKSL AQTSKTTTAV YVFFLSSLLQ PRGGSQEHHL
SAHLRGLCSL AADGIWNQKI LFEECDLRNH GLQKADISAF LRMNLFQKEV DCETFYSFIH
MTFQEFFAAM YYLLEEEEEG VVRKPGSCSK LPNRDVTVLL ENYGKFEKGY LIFVVRFLFG
LVNQERTSYL EKKLSCKISQ QIRVELLKWI EAKAKAKKLQ IQPSQLELFY CLYEMQEEDF
VHRAMDHFPK IEINLSTRMD HVVSSFCIEN CRSVESLSLG FLHNSPKEEE EEEEEEDSQH
PDMGQGVLPS PQATCSNRLA NYLTSSFCRG LFSVLCTNPS LTELDLSDNT LGDPGMRVLC
ETLRHPGCNI QRLWLGRCGL SEQCCFDISL VLSSSQKLVE LDLSDNALGD FGIRLLCVGL
THPLCSLKKL WLVSCFLTSA CCQDLASVLS TNQSLTRLYV GENALGDSGV EMLCEKVKHP
GCNLQKLGLV NSGLTAACCS ALSLALSANQ NLTHLYLRGN ALGDVGAKRL CEGLSHPNCK
LQLLELDSCN LTSRSCWYLC TLLTSTQSLR KLSLGNNDLG DLGVMMLCEV LKHGDCLLQS
LQ
//
