ID L9J8R3_TUPCH Unreviewed; 1313 AA.
AC L9J8R3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 1 {ECO:0000313|EMBL:ELW46901.1};
GN ORFNames=TREES_T100004593 {ECO:0000313|EMBL:ELW46901.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW46901.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR EMBL; KB321178; ELW46901.1; -; Genomic_DNA.
DR STRING; 246437.L9J8R3; -.
DR eggNOG; KOG0401; Eukaryota.
DR InParanoid; L9J8R3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF10; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|EMBL:ELW46901.1};
KW Protein biosynthesis {ECO:0000313|EMBL:ELW46901.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 954..1076
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1142..1312
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 79..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 144982 MW; 4EF7DDC28B34AB4C CRC64;
MMIPSQLSYT ASQGAYYIPG QGRSTYVVPT QQYPVQPGAP SFYPGASPTE FGTYALFPQI
RIRDPNQGGK DITEEIMSGA RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPEPILEVEV
TLSKPVPEAE FSSSPLQVST PLASHTVEIH EPNGVVPSDD LEPEVESSPE LAPLPSPARP
SESPVPIAPT AQPEELLNGA PSPPALDLSP VSEPEEQAKE VTASVAPATV PSATSAVASP
ATSPVQEEDM EEEEEEEEAG EAGEAESEKG AEELLPSETA SIPAHLSQNV EAAAATQVAV
SVPKRRRKIK DLNKKEAVGD LLDAFKEVSP AVPEVENQPP AGSSPGPETE GSSVPPRPED
ADETWDSKED KIHNAENIQP GEQKYEYKSD QWKPLNLEEK KRYDREFLLG FQFIFASMQK
PEGLPHISDV VLDKANKTPL RPLDPTRLQG INCGPDFTPS FANLGRPALS NRGPPRGGPG
GELPRGPDLF RRVRSILNKL TPQMFQQLMK QVTQLAIDTE ERLKGVIDLI FEKAISEPNF
SVAYANMCRC LMALKVPTTE KPTVTVNFRK LLLNRCQKEF EKDKDDDEVF EKKQKEMDEA
ATAEERGRLK EELEEARDIA RRRSLGNIKF IGELFKLKML TEAIMHDCVV KLLKNHDEES
LECLCRLLTT IGKDLDFEKA KPRMDQYFTQ MEKIIKEKKT SSRIRFMLQD VLDLRRSNWV
PRRGDQGPKT IDQIHKEAEL EEHREHIKVQ QLMAKGSDKR RGGPPGPPIS RGLPLVDDGG
WNTVPISKGS RPIDTSRITK ITKPGSIDSN NQLFAPGGRL SWGKGSSGGS GAKPSDAGVR
PSSHSAVQVR DCLSSRSSLS RERGEKAGDR GDRLERSERG ADRGDRLDRA RTPATKRSFS
KEVEERSRER PSQPEGLRKA ASLTEDRDRG RDAGKREAAL PAGSPPKAAL SEEELEKKSK
AIIEEYLHLN DMKEAVQCVQ ELASPSLLFI FVRHGIESTL ERSAVTREHM GQLLHQLLCA
GHLSTAQYYQ GLYEILELAE DMEIDIPHVW LYLAELVTPI LQEGGVPMGE LFREITKPLR
PLGKATSLLL EILGLLCRSM GPKKVGTLWR EAGLSWKEFL PEGQDVGAFA AEQKVEYTLG
EESEAPGPRA LPSEELSRQL ENLLKEGSSN QRVSDWIEAN LSEQQVASNT LVRALMTAVC
SSAIIFESPL RVDVAVLKAR AKLLQKYLCD EQKELQALYA LQALVVTLEQ PANLLRTFFD
ALYDEDVVKE DAFYSWEGSK DPSEQQGKGV ALKSVTAFFK WLREAEEEES DHN
//
