ID L9JEV8_TUPCH Unreviewed; 1970 AA.
AC L9JEV8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Low-density lipoprotein receptor-related protein 4 {ECO:0000313|EMBL:ELW48854.1};
GN ORFNames=TREES_T100014293 {ECO:0000313|EMBL:ELW48854.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW48854.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KB321021; ELW48854.1; -; Genomic_DNA.
DR STRING; 246437.L9JEV8; -.
DR eggNOG; KOG1215; Eukaryota.
DR InParanoid; L9JEV8; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 15.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:ELW48854.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELW48854.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1789..1812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..499
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 546..588
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 589..631
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 632..675
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 676..718
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 851..893
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 894..936
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 937..980
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 981..1023
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1159..1201
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1202..1244
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1245..1288
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1289..1330
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1463..1505
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1506..1548
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1549..1592
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1593..1634
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1916..1970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1731..1751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1953..1970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 117..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 137..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 144..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 156..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 183..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 214..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 221..239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 233..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 257..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 264..282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 276..291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 297..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 304..322
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 316..331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 336..348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 343..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 355..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 378..390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 385..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1970 AA; 218096 MW; B09D1E6AA668153E CRC64;
MRALEPWGFL HSGHESSDSS PYAPRGSSGT AGSQHLPLVV FRVPSPGCGQ SASCPGSSLG
EGAAGLEKGL RRNVGKKLLE ALAGLASSPE CACGRSHFTC AVSALGECTC IPAQWQCDGD
NDCGDHSDED GCMLPTCSPL DFHCDNGKCI RRSWVCDGDN DCEDDSDEQD CPPRECEEDE
FPCQNGYCIR SLWHCDGDND CGDNSDEQCD MRKCSDKEFR CSDGSCIAEH WYCDGDTDCK
DGSDEESCPS AVPAPPCNLE EFQCAYGRCI LDIYHCDGDD DCGDWSDESD CSSHQPCRSG
EFMCDSGLCI NAGWRCDGDA DCDDQSDERN CTTSMCTAEQ FRCRSGRCVR LSWRCDGEDD
CADNSDEENC ENTGSPQCAS DQFLCWNGRC IGQRKLCNGV NDCGDNSDES PQQNCRPRTG
EENCNVNNGG CAQKCQMVRG AVQCTCHTGY RLTEDGHTCQ DVNECAEEGY CSQGCTNSEG
AFQCWCEAGY ELRPDRRSCK ALGPEPVLLF ANRIDIRQVL PHRSEYTLLL NNLENAIALD
FHHQRELVFW SDVTLDRILR ANLNGSNVEE VVSTGLESPG GLAVDWVHDK LYWTDSGTSR
IEVANLNGAH RKVLLWQNLE KPRAIALHPM EGTIYWTDWG NTPRIEASSM DGSARRIIAD
THLFWPNGLT IDYAGHRMYW VDAKHHVIER ANLDGSHRKA VISQGLPHPF AITVFEDSLY
WTDWHTKSIN SANKFTGKNQ EIIRNKLHFP MDIHTLHPQR QPAGKNRCGD NNGGCTHLCL
PSGQNYTCAC PTGFRKISSL ACAQSLDKFL LFARRMDIRR ISFDTEDLSD DVIPLADVRS
AVALDWDSRD DHVYWTDVST DTISRAKWDG TGQEVVVGTS LESPAGLAID WVTNKLYWTD
AGTDRIEVAN TDGSMRTVLI WENLDRPRDI VVEPMGGYMY WTDWGASPKI ERAGMDASGR
QVIISSNLTW PNGLAIDYGS QRLYWADAGM KTIEFAGLDG SKRKVLIGSQ LPHPFGLTLY
GERIYWTDWQ TKSIQSADRL TGMDRETLQE NLENLMDIHV FHRRRPPVST PCAVENGGCS
HLCLRSPNPS GFSCTCPTGI NLLPDGKTCS PGMNSFLIFA RRIDIRMVSL DIPYFADVVV
PVNITMKNTI AIGVDPQEGK VYWSDSTLHR ISRASLDGSQ HEDIITTGLQ TTDGLAVDAI
GRKVYWTDTG TNRIEVGNLD GSMRKVLVWQ NLDSPRAIVL YHEMGFMYWT DWGENAKLER
SGMDGSDRTV LINNNLGWPN GLTVDKASSQ LLWADAHTER IEAADLNGAN RHTLVSPVQH
PYGLTLLDSY IYWTDWQTRS IHRADKGTGS NVILVRSNLP GLMDIQAVDR AQPLGLNKCG
SRNGGCSHLC LPRPSGFSCA CPTGIQLKGD GRTCDPSPET YLLFSSRGSI RRISLDTSDH
TDVHVPVPEL NNVISLDYDS VDGKVYYTDV FLDVIRRADL NGSNMETVIG RGLKTTDGLA
VDWVARNLYW TDTGRNTIEA SRLDGSCRKV LVNNSLDEPR AIAVFPRKGY LFWTDWGHIA
KIERAHLDGS ERKVLINTDL GWPNGLTLDY DTRRIYWVDA HLDRIESADL NGKLRQGLVS
HVSHPFALTQ DRWIYWTDWQ TKSIQRVDKY SGRNKETVLA NVEGLMDIIV VSPQRQTGTN
ACGVNNGGCT HLCFARALDF VCACPDEPDG QPCSLVPGLV PPAPRATSMS EKSPVLPNTP
PTTLHSATTR TRASLEEAEG RCSERDARLG LCAHSNEAVP AAPGEGLHVS YAIGGLLSIL
LVLVVIAALM LYRHKKSKFT DPGMGNLTYS NPSYRTSTQE VKIEAVPKPA MYNQLCYKKE
GGPDHNYTKE KIKIVEGICL LSGDEAEWDD LKQLRSSRGG LLRDHVCMKT DTVSIQASSG
SLDDTETEQL LQEEQSECSS VHTAATPERR GSLPDTGWKH ERKLSSESQV
//
